From:
Sukie Crandall
Date: 2010-01-21 06:02:26 UTC
Subject: [ferrethealth] abstracts
To: fhl <ferrethealth@yahoogroups.com>
Yet more genome work indicates that the FIP-like coronavirus in=20
ferrets is most closely related to ECE:
http://www.ncbi.nlm.nih.gov/pubmed/20079778
> Comparative sequence analysis of the distal one-third of the genomes=20
> of a, systemic and an enteric ferret coronavirus
>
> Annabel G. Wise, Matti Kiupel, Michael M. Garner, April K. Clark and=20
> Roger K. Maes
>
> Diagnostic Center for Population and Animal Health, 4125 Beaumont=20
> Road, Lansing, MI 48909, Michigan State University, East Lansing, MI=20
> 48824, USA
>
> Department of Pathobiology and Diagnostic Investigation MI 48824, USA
>
> Department of Microbiology and Molecular Genetics, Michigan State=20
> University, East Lansing, MI 48824, USA
>
> Northwest ZooPath, 654 West Main, Monroe, WA 98272, USA
>
>
> Received 3 September 2009;
> revised 21 December 2009;
> accepted 23 December 2009.
> Available online 15 January 2010.
>
> Abstract
> Ferret systemic coronavirus (FRSCV) infection is associated with an=20
> emerging, highly fatal disease of ferrets. Enhanced macrophage=20
> tropism and the resulting induction of pyogranulomatous lesions are=20
> shared with feline infectious peritonitis virus (FIPV) infection in=20
> cats, but are not features of ferret enteric coronavirus (FRECV)=20
> infection. Comparative sequence analysis of the distal one-third of=20
> the genomes of one FRSCV and one FRECV strain showed that these two=20
> ferret coronaviruses share >96% nucleotide sequence identities in=20
> the membrane (M), nucleocapsid (N) and non-structural protein genes=20
> (partial polymerase, open reading frames [ORFs] 3 and 7b). The=20
> envelope (E) protein gene showed a moderate nucleotide sequence=20
> similarity of 91.6%. In contrast, nucleotide and amino acid sequence=20
> similarities observed with the spike (S) protein were only 79.5% and=20
> 79.6%, respectively. Twenty-one amino acid differences within a 195=20
> to 199-amino acid C-terminal portion of the S protein were conserved=20
> between 3 strains each of FRSCV and FRECV. Both systemic and enteric=20
> strains were found to carry a single ORF 3 gene with truncated=20
> proteins observed in two out of three FRSCV strains examined. The=20
> two enteric strains analyzed each contained an intact ORF 3 gene.=20
> Phylogenetically, FRSCV is more closely related to FRECV than to=20
> other group 1 coronaviruses.
>
> Keywords: Coronavirus; Ferret; FIP-like disease; Mustelo putorius=20
> furo; Systemic disease
>
Four treatments to suppress ovarian activity are compared:
http://www.ncbi.nlm.nih.gov/pubmed/20081178
> Comparison of four treatments to suppress ovarian activity in=20
> ferrets (Mustela putorius furo)A. Proh=E1czik, DVM1,4, M. Kulcs=E1r,=20
> DVM, PhD1, T. Trigg, BRurSc, MSc, PhD2, M. A. Driancourt, PhD,=20
> DipECAR3 andG. Huszenicza, DVM, PhD, DSc, DipECAR1
> 1 Faculty of Veterinary Science, Szent Istv=E1n University, Istv=E1n=20
> utca 2, 1078 Budapest, Hungary
> 2 Peptech Animal Health, Macquarie Park, NSW 2113, Australia
> 3 Intervet Pharma R&D, Intervet Schering-Plough Animal Health, rue=20
> Olivier de Serres, Angers Technopole, BP 67131, 49071 Beaucouz=E9=20
> Cedex, France
> 4 Intervet Pharma R&D, Intervet Schering-Plough Animal Health, rue=20
> Olivier de Serres, Angers Technopole, BP 67131, 49071 Beaucouz=E9=20
> Cedex, France
>
>
> Twenty-five ferret jills were randomly allocated to five groups of=20
> five animals; they were treated either before the breeding season=20
> with 15 mg medroxyprogesterone acetate (MPA), with 40 mg=20
> proligestone or with a slow-releasing device containing 4.7 mg of=20
> the gonadotropin-releasing hormone (GnRH) agonist deslorelin acetate=20
> (srGnRH), or at spring oestrus with 100 iu human chorionic=20
> gonadotropin (hCG), or were left untreated and mated. All the=20
> ferrets were assessed for signs of oestrus and their ovarian=20
> response was monitored by individual faecal progesterone metabolite=20
> (P4-met) profiles. The mean (sd) durations of treatment-induced=20
> ovarian quiescence were 94 (18), 99 (40), 53 (9) and 698 (122) days=20
> in the group treated with MPA, proligestone, hCG and srGnRH,=20
> respectively (P<0.001). Treatment with hCG and srGnRH proved to be=20
> the safest, while MPA treatment was associated with most side=20
> effects. Both MPA and proligestone treatments caused alopecia in one=20
> ferret per group, and after the first return to oestrus and mating=20
> an MPA-treated jill had a premature delivery and developed a=20
> purulent vaginal discharge. At the first post-treatment mating, the=20
> fertility (expressed as the percentage of ferrets mated in the group=20
> that produced a litter) was 75 per cent in the MPA-treated group, 60=20
> per cent in the proligestone-treated group, 75 per cent in the hCG-
> treated group and 0 per cent in the srGnRH-treated group; in the=20
> control group, fertility was 100 per cent at mating in spring and 60=20
> per cent at mating in summer. Three srGnRH-treated jills conceived=20
> at the second post-treatment oestrus.
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
HAPPY: http://www.6footsix.com/my_weblog/2010/01/high-fives-for-happiness.=
html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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