From:
Sukie Crandall
Date: 2010-01-23 16:59:20 UTC
Subject: [ferrethealth] hormonal perturbation due to stain block (POSSIBLE VET STUDENT SENIOR PROJECT?) abstract
To: fhl <ferrethealth@yahoogroups.com>, Ferret Mailing List <ferret-l@LISTSERV.FERRETMAILINGLIST.ORG>
I wonder which other types of hormonal perturbations show up in=20
species other than humans? Ferrets spend a LOT of time in many=20
people's carpets.
>
> <http://www.sciencenews.org/view/generic/id/55542/title/Common_stain_repe=
llent_linked_to_thyroid_disease
> >
Some segments from Science News:
>> COMMON STAIN REPELLENT LINKED TO THYROID DISEASE
>> Long-term health study shows connection with blood levels of=20
>> perfluorooctanoic acid
>> By Rachel Ehrenberg
>> Web edition : Friday, January 22nd, 2010
...
>> Stain-repelling chemicals help keep carpets, upholstery and=20
>> clothing clean =97 but
...
>> Higher blood levels of the synthetic chemical perfluorooctanoic=20
>> acid, or PFOA, are linked to thyroid diseases, scientists report=20
>> online in Environmental Health Perspectives. It is the first report=20
>> of such a connection between the widely used chemical and thyroid=20
>> diseases in people and should prompt further studies, scientists say.
...
>> study coauthor Tamara Galloway of the University of Exeter in=20
>> England. The researchers analyzed data from theNational Health and=20
>> Nutrition Examination Survey, or NHANES, conducted by the [CDC]
...
>> The researchers analyzed data from nearly 4,000 adults taken for=20
>> NHANES from 1999 to 2006 and looked at blood levels of PFOA.
...
>> coatings that make firefighter gear heat-resistant and that keep=20
>> microwave popcorn bags from seeping grease and carpets from=20
>> absorbing spills. The team looked for associations between blood=20
>> levels of PFOA and each of several diseases... People with the=20
>> higher PFOA levels were more than twice as likely to have thyroid=20
>> diseases
...
>> PFOA is a type of perfluorochemical, or PFC, that has been=20
>> manufactured directly and is a byproduct of producing other=20
>> chemicals. Since the 1950s, PFCs have been used to make numerous=20
>> products, including lubricants, paper and textile coatings,=20
>> polishes, food packaging and fire-retardant foams.
>>
>> These compounds of carbon chains decked out with fluorine atoms are=20
>> extremely stable and persistent in the environment, people and=20
>> wildlife, and NHANES data suggest that more than 98 percent of=20
>> Americans have PFOA in their blood. Exposure routes aren=92t clear,=20
>> but probably include contaminated drinking water, dust and contact=20
>> with products.
...
>> animal studies suggest that PFOA may meddle with the balance of=20
>> hormones in the body
So far I don't find any ferret exposure studies. It might be=20
interesting if some vets began looking at PFOA blood levels in ferrets=20
with adrenal disease and insulinoma to see if in households with young=20
cases of either of these diseases or many cases of these diseases the=20
ferrets had higher PFOA levels than in households without.
THIS POSSIBLY WOULD BE A WONDERFUL VETERINARY STUDENT SENIOR PROJECT!
Abstract:
> Environ Health Perspect. 2010 Jan 7. [Epub ahead of print]
> Association Between Serum Perfluoroctanoic Acid (PFOA) and Thyroid=20
> Disease in the NHANES Study.
> Melzer D, Rice N, Depledge MH, Henley WE, Galloway TS.
> University of Exeter.
> BACKGROUND: Perfluorooctanoic acid (PFOA, 'C8') and perfluoroctane=20
> sulphonate (PFOS) are stable compounds with many industrial and=20
> consumer uses. Their persistence in the environment plus toxicity in=20
> animal models has raised concern over low-level chronic exposure=20
> effects to human health. OBJECTIVES: To estimate associations=20
> between serum PFOA and PFOS concentrations and thyroid disease=20
> prevalence in representative samples of the United States general=20
> population. METHODS: Analyses of PFOA/PFOS against disease status in=20
> the Health and Nutrition Examination Survey (NHANES) 1999-2000,=20
> 2003-2004 and 2005-2006. Included were 3974 adults with measured for=20
> PFC concentrations. Regression models were adjusted for age, sex,=20
> race/ethnicity, education, smoking status, body mass index, and=20
> alcohol intake. RESULTS: In women, the NHANES weighted prevalence of=20
> reporting any thyroid disease was 16.18% (n=3D292), for men 3.06%=20
> (n=3D69): prevalence of current thyroid disease taking related=20
> medication was 9.89% (n=3D163) for women and 1.88% (n=3D46) for men. In =
> fully adjusted logistic models, women with PFOA >/=3D5.7ng/ml (top=20
> population quartile '4') were more likely to report current treated=20
> thyroid disease: Odds Ratio =3D 2.24 (95%CI: 1.38 to 3.65, p=3D0.002) =
> compared to PFOA </=3D4.0ng/ml (quartiles 1&2). In men, there was a=20
> near significant similar trend OR=3D2.12 (CI 0.93 to 4.82, p=3D0.073). =
> For PFOS in men, a similar association was present comparing those=20
> with PFOS>/=3D36.8 ng/ml (Q4) to those with PFOS concentrations </
> =3D25.5 ng/ml (Q1&Q2): OR for treated disease 2.68 CI: 1.03 to 6.98,=20
> p=3D0.043. In women this association was not significant. CONCLUSIONS: =
> Higher concentrations of serum PFOA and PFOS are associated with=20
> current thyroid disease in the US general adult population. More=20
> work is needed to establish the mechanisms involved and to exclude=20
> confounding and pharmacokinetic explanations.
> PMID: 20089479
No adrenal studies in relation to PFOA come up but some pancreatic=20
ones do in a search of PubMed. None are ferret studies.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
HAPPY: http://www.6footsix.com/my_weblog/2010/01/high-fives-for-happiness.=
html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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