From:
Sukie Crandall
Date: 2010-01-24 17:58:17 UTC
Subject: [ferrethealth] Re: Mouth Tumor & Reddened skin
To: fhl <ferrethealth@yahoogroups.com>
So, the multinucleated cells were in the pus rather than the tumor
itself?
I am going to go out on a limb here and say that currently,
although there are many options, I am leaning toward
pemphigus if the skin blisters because ferrets DO get that,
it produces reddened skinand it can
produce oral lesions with multinucleated cells.
Pemphigus is treatable. See the separate FHL Archives:
http://ferrethealth.org/archive/
and just put that word in the box for message content
(body of message), leave the other two boxes empty
and click on the search button.
http://ferrethealth.org/archive/YG119
http://ferrethealth.org/archive/YG752
Yeah, I did a bit of searching:
multinucleated +pus +oral +ferret
brings up over 600 results on Google.
My ISP is having problems today so I could not see the content in
http://www.oie.int/boutique/extrait/delisle.pdf
Again, could not see content, but compromised ferrets sometimes break
with Avian mycobacterial infections
(Used to be called Avian TB) and can get some related infections:
http://www.oie.int/boutique/extrait/delisle.pdf
Many things come up on a search of
multinucleated +pus
https://content.nejm.org/cgi/reprint/350/7/e6.pdf?ck=nck
comes up with
"Use of Multinucleated Giant Cells
to Diagnose a Viral Eruption"
which may be a good read. Viruses as causes of multinucleated pus
came up a LOT in my searching.
Not sure if these will help:
http://jcp.bmj.com/content/46/8/709.abstract
(I wonder if any ferrets have had Wegener's granulomatosis
documented, or "strawberry gums" from other causes.)
This would not open fully (ISP having some troubles today
with local service on and off.) but it looks like it is from
page 16:
> Atlas of serous fluid cytopathology: a guide to the cells of ... -
> Google Books Result
> by Arthur I. Spriggs, Michael M. Boddington - 1989 - Medical - 144
> pages
> Many of them are dead or dying neutrophils. but whereas in pus these
> form a ... Macrophages of various sizes are present and often
> include multinucleate ...
and this from page 86 of another:
> Pathology: a core text of basic pathological processes with ... -
> Google Books Result
> by Paul Bass, Norman Carr, Clair Du Boulay - 2004 - Medical - 127
> pages
> Microscopically, the outer surface may be coated with pus and
> fibrin, the wall will ... large cells that have numerous nuclei
> (multinucleate giant cells). ...
So, what I am wondering is if a specimen of the pus may be
insufficient for knowing what is going on IF there is a malignancy
rather than an infection lesion.
multinucleate +pus +oral
Gets things like:
http://pathmicro.med.sc.edu/virol/herpes.htm
(So some types of infections can cause that pus result it appears.
Just on a quick check at that site -- and these are human results --
herpes simplex, chicken pox, Burkitt's lymphoma, cytomegalovirus
all show multinucleated cells as part of the cytology. There may
be multiple possible causes.)
Okay, that can happen in pemphigus and ferrets do get that:
<http://www.ijdvl.com/article.asp?issn=0378-6323;year=1992;volume=58;issue=1;spage=20;epage=22;aulast=Pasricha
>
Another that won't open seems to indicate that dental problems can
result in cysts with such cells:
A Dentigerous Cyst with Antro-Oral Fistula
by M Setiya - 2007 - Cited by 1 - Related articles - All 2 versions
Many multi-nucleated foreign body type giant cells were found in
fibrous granulations from the neck of the tooth. The pus from the
antrum produced a growth ...
and this comes up slowly:
http://www.scribd.com/doc/15614146/Benign-Oral-Tumors-of-Mesenchymal-Tissue-Origin
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
HAPPY: http://www.6footsix.com/my_weblog/2010/01/high-fives-for-happiness.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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