From:
Sukie Crandall
Date: 2010-04-03 14:52:10 UTC
Subject: Re: [ferrethealth] Re: Deslorelin side effects
To: ferrethealth@yahoogroups.com
On Apr 2, 2010, at 11:32 PM, Jeff wrote:
> Thanks Tressie, Christina, and others for the information you have
> supplied. A related question, and a concern of my vet, is whether or
> not giving a deslorelin implant to a ferret without adrenal disease
> can cause Addisons Disease.
>
I can't see what the mechanism would be for that. Ferrets with
adrenal disease are typically over-producing hormones, not over -
producing the corticosteroids, so the effect that this class of drugs
has on corticosteroid production should be the same with or without
adrenal disease.
Lupron is in the same class of drugs and I have not heard of either
causing Addisons. That is not to say that there might not be some
rare situations in which the class of drug can, but so far I don't
find any studies or reputable resources that mentioned that unless I
missed it in skimming. Both the hormones and the steroids are made in
the cortex of the adrenal but this class of drugs does not damage the
cortex nor have broad suppressant activities on the adrenals.
Instead, the drug class which includes deslorelin and Lupron is
designed to alter hormone levels themselves.
What CAN cause Addisons (and other times just does not work for
treating adrenal disease) is Lysodren/mitotane but that is an entirely
different sort of medication which works in a totally different way,
with adrenal suppression, when it affects the adrenals though its
actual mode of action is not known:
http://www.drugs.com/pro/lysodren.html
It's normally a chemotherapeutic drug but in some had adrenal
responses and in others does not.
The class of drugs which contains Suprelorin implants and Lupron
depots affects hormonal actions instead. They are gonadotropin-
releasing hormone (GnRH) agonists. An agonist mimics a natural
substance and binds to its receptor site. See:
http://ferrethealth.org/archive/FHL9686
http://ferrethealth.org/archive/FHL9453
http://www.medicinenet.com/leuprolide/article.htm
and here is why the daily form of Lupron can worsen adrenal disease
but the depot works:
http://www.medicinenet.com/leuprolide/article.htm
says
> When given continuously, leuprolide initially increases the
> production of LH and FSH as well as testosterone and estrogen;
> however, after a few weeks of continuous leuprolide, the levels of
> LH and FSH drop because the pituitary gland stops responding to GnRH
> and leuprolide. This leads to a decrease in the production of
> estrogen and testosterone.
and more can be found here on that:
http://www.miamiferret.org/24hr_lupron.htm
To cause Addison the drug would have to decrease adrenal
corticosteroid production.
The grouping of drugs that includes Lupron and Suprelorin also
includes some others such as Trelstar.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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