From:
AFERRETVET@cs.com
Date: 2010-04-10 19:14:35 UTC
Subject: [ferrethealth] Re:Casodex vs Finasteride
To: ferrethealth@yahoogroups.com
Hi Marci
You have a good question about how to treat your
Loki with adrenal disease and a prostate problem.
Unfortunately this a somewhat common problem for
male ferrets with adrenal disease.
Because the prostate problem is a serious and potentially fatal
condition, you need to treat aggressively. First you need to lower the
hormones (DHT and Estrogen) that are causing the prostate to enlarge.
This can be done with Lupron or Deslorelin with melatonin. Next you need
to further lower the DHT level with either Avodart, Proscar/Propecia, or
Casodex.
Avodart and Proscar/Propecia both stop the production of DHT. Avodart may
be the slightly better option. Casodex on the other hand just blocks the
DHT receptors on the prostate. It does not lower the hormone level.
Actually
the DHT levels will increase with Casodex. Thus Avodart or Proscar/Propecia
are
the better options, but they need to be used with Lupron or Deslorelin and
melatonin. Most of the prostate cases will have a bacterial infection too.
Thus an antibiotic (Zeniquin, Baytril, or Trimeth/sulfa) may be needed also.
Metacam is a NSAID product that will help with pain but does little to the
prostate.
I would start him on Lupron as soon as possible, but it does not have to be
a whooping dose. Just 200 mcg should be enough to control the adrenal
disease and help shrink the prostate. Likewise Proscar/Propecia at 1 mg
once a day for the first 30-60 days in a row. Usually by then the prostate
is small enough to reduce the dose to just 0.1 mg once a day. Again with
Lupron once a month. The dose for Avodart (if price is no problem) is
0.05 mg once a day for 30-60 days. May be able to reduce it to every other
day after the prostate is small enough to not cause any urination problems.
Hope that helps,
Jerry Murray, DVM
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