From:
Sukie Crandall
Date: 2010-05-03 16:58:25 UTC
Subject: [ferrethealth] not ferret but the principal may apply, and might be of interest for things like JL
To: fhl <ferrethealth@yahoogroups.com>, fg <ferret-genetics@yahoogroups.com>
http://www.eurekalert.org/pub_releases/2010-05/uol-dd043010.php
Various possible genetic contributors to malignancy
development have been discussed here before, and
one of the forms of lymphoma appears to have a viral
trigger which happens abut 2 to 3 years before onset.
Another form of lymphoma that has long been thought
to be likely to have a genetic component, or a viral
exposure component, or both is Juvenile Lymphoma.
Have any breeders here followed this up to see if multiple
ferrets in the same lines, or from the same pregnancy get J
L or have offspring more inclined to get JL?
I could carry the entire article since it is a press release,
but these sections should suffice:
> Professor Constanze Bonifer (University of Leeds) and
> Dr Stephan Mathas (Charit=E9, MDC) who co-led the study
> suspect that these pieces of 'junk' DNA, called
> 'long terminal repeats', can play a role in other forms of cancer
> as well. The work is published in Nature Medicine.*
> 'Long terminal repeats' (LTRs) are a form of
> 'junk DNA- genetic material that has accumulated
> in the human genome over millions of years. Although
> LTRs originate from viruses and are potentially harmful,
> they are usually made inactive when embryos are developing in the=20
> womb.
>
> If this process of inactivation doesn't work, then the LTRs
> could activate cancer genes, a possibility that was suggested
> in previous animal studies. This latest research has now
> demonstrated for the first time that these 'rogue' active
>
> LTRs can drive the growth of cancer in humans.
>
> They found that the lymphoma cells' growth was
> dependent on a receptor that normally regulates
> the growth of other immune cells, but it is not usually
> found in B-cells. However in this case, the
> Hodgkin-/Reed Sternberg cells 'hijacked' this receptor
> for their own purposes by activating some of the
> 'junk DNA'. In fact the lymphoma cells activated hundreds,
> if not thousands, of LTRs all over the genome, not just one.
>
> Hodgkin-/Reed Sternberg cells may not be the only cells
> that use this method to subvert normal controls of cell growth.
> The researchers found evidence of the same LTRs activating
> the same growth receptor in anaplastic large cell lymphoma,
> another blood cancer.
>
> The consequences of such widespread LTR activation are
> currently still unclear, according to the study's authors.
> Such processes could potentially activate other genes
> involved in tumour development. It could also affect the
> stability of chromosomes of lymphoma cells, a factor that
> may explain why Hodgkin-/Reed Sternberg cells gain many
> chromosomal abnormalities over time and become more and more=20
> malignant.
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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