From:
Sukie Crandall
Date: 2010-05-11 23:19:16 UTC
Subject: [ferrethealth] abstract
To: fhl <ferrethealth@yahoogroups.com>
> 1. J Vet Diagn Invest. 2010 May;22(3):469-73.
> Malignant B-cell lymphoma with Mott cell differentiation in a ferret
> (Mustela putorius furo).
> Gupta A, Gumber S, Schnellbacher R, Bauer RW, Gaunt SD.
> Department of Pathobiological Sciences, School of Veterinary
> Medicine, Louisiana State University, Skip Bertman Drive, Baton
> Rouge, LA 70803.
> A 3.5-year-old, male, neutered ferret (Mustela putorius furo) was
> presented with a 3-day history of lethargy and anorexia. Splenic
> aspirates revealed high numbers of intermediate-sized lymphocytes
> and Mott cells interpreted as lymphoma with Mott cells. The ferret
> was euthanized because of a poor clinical prognosis. Postmortem
> examination revealed markedly enlarged spleen and lymph nodes, with
> multifocal white nodules in the liver parenchyma. Histologically,
> the spleen had multifocal large nodules composed of neoplastic
> lymphocytes with frequent Mott cells. Similar neoplastic cells were
> present in the sections of liver, lymph nodes, and bone marrow.
> These cells were cluster of differentiation (CD)3-negative,
> CD79alpha-positive, and lambda light-chain-positive. Electron
> microscopy revealed that the cytoplasm of the neoplastic Mott cells
> had increased, disorganized, dilated, rough endoplasmic reticulum
> containing electron-dense immunoglobulin. On the basis of cytologic,
> histopathologic, immunohistochemical, and electron microscopic
> findings, a malignant B-cell lymphoma with Mott cell differentiation
> was diagnosed. PMID: 20453231 [PubMed - in process]
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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