Message Number: FHL11613 | New FHL Archives Search
From: Sukie Crandall
Date: 2010-05-28 17:47:42 UTC
Subject: [ferrethealth] Re: Hemolytic Ecoli
To: fhl <>, Barbara Clay <>

Re: E. coli

There does not appear to be much that can be done beyond supportive
care, and IV appears to be the single most important thing to provide.

A bit more on treatment and future approaches:
> Antidote
> None available
> Supportive Care
> Maintain fluid and electrolytes levels, monitor and support kidney
> function
> Steam treatment, oxidizing agents such as bleach and reactive
> sterilants such as glutaraldehyde.
> Early Diagnosis and Improved Patient Outcome
> Early diagnosis of STEC infection is important for determining the
> proper treatment promptly. Initiation of parenteral volume expansion
> early in the course of O157 STEC infection might decrease renal
> damage and improve patient outcome (14). Conversely, certain
> treatments can worsen patient outcomes; for example, antibiotics
> might increase the risk for HUS in patients infected with O157 STEC,
> and antidiarrheal medications might worsen the illness (32). Early
> diagnosis of STEC infection also might prevent unnecessary
> procedures or treatments (e.g., surgery or corticosteroids for
> patients with severe abdominal pain or bloody diarrhea) (33--35).

> Curr Opin Gastroenterol. 2008 Jan;24(1):38-47.
> Pathogenesis and treatment of Shiga toxin-producing Escherichia coli
> infections.
> Serna A 4th, Boedeker EC.
> Division of Gastroenterology/Hepatology, Department of Internal
> Medicine, University of New Mexico School of Medicine, Albuquerque,
> NM 87131-0001, USA.
> Abstract
> PURPOSE OF REVIEW: Shiga toxin-producing Escherichia coli cause
> hemorrhagic colitis and hemolytic uremic syndrome. We will summarize
> the literature on incidence and outcomes of these infections, and
> then review the pathogenesis to explain the current recommendations
> against antibiotic use and to suggest alternative therapies. RECENT
> FINDINGS: Shiga toxin-producing E. coli continue to be prevalent in
> the industrialized world because of dissemination in food products
> contaminated by ruminant feces. Declines in ground beef-related
> outbreaks have been matched by increased cases related to green
> vegetables. Fifteen percent of patients infected with E. coli
> O157:H7 progress to hemolytic uremic syndrome, but this figure may
> reach 50% if antibiotics are used. Mechanisms for bacteriophage
> induction causing Shiga toxin production, and for Shiga toxin
> dissemination to endothelium in gut, kidney and brain, may explain
> the negative effects of antibiotics and lead to rational therapies.
> Shiga toxin binders were not effective in clinical trials, but more
> avid binding agents may be. Current treatment recommendations are to
> maintain hydration to prevent thrombotic complications. Human
> vaccines are unlikely to be utilized. Cattle vaccines may prove the
> most significant approach to this disease. SUMMARY: Improved
> understanding of Shiga toxin-producing Escherichia coli
> pathophysiology and progression to hemolytic uremic syndrome
> provides the basis for prevention, prophylactic and treatment
> strategies.
> PMID: 18043231 [PubMed - indexed for MEDLINE]

E. coli can get on plant foods, too, when there is run-off from fields
with the waste of infected cattle, or when people working the fields
or processing locations have become infected and do not use careful
sanitary measures.

Sukie (not a vet)

Recommended ferret health links:
all ferret topics:

"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)


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