From:
Sukie Crandall
Date: 2010-05-28 17:47:42 UTC
Subject: [ferrethealth] Re: Hemolytic Ecoli
To: fhl <ferrethealth@yahoogroups.com>, Barbara Clay <rocky_rrr@yahoo.com>
Re: E. coli
There does not appear to be much that can be done beyond supportive
care, and IV appears to be the single most important thing to provide.
A bit more on treatment and future approaches:
http://www.cbwinfo.com/Biological/Toxins/Verotox.html
includes:
> Antidote
> None available
> Supportive Care
> Maintain fluid and electrolytes levels, monitor and support kidney
> function
> Inactivation [THIS WOULD BE IN THE EXPOSED ENVIRONMENT SUCH AS
> COUNTER TOPS, GRILLS, CUTTING BOARDS, ETC.]
> Steam treatment, oxidizing agents such as bleach and reactive
> sterilants such as glutaraldehyde.
http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5812a1.htm
includes:
> Early Diagnosis and Improved Patient Outcome
> Early diagnosis of STEC infection is important for determining the
> proper treatment promptly. Initiation of parenteral volume expansion
> early in the course of O157 STEC infection might decrease renal
> damage and improve patient outcome (14). Conversely, certain
> treatments can worsen patient outcomes; for example, antibiotics
> might increase the risk for HUS in patients infected with O157 STEC,
> and antidiarrheal medications might worsen the illness (32). Early
> diagnosis of STEC infection also might prevent unnecessary
> procedures or treatments (e.g., surgery or corticosteroids for
> patients with severe abdominal pain or bloody diarrhea) (33--35).
>
http://www.cdc.gov/mmwr/pdf/rr/rr5812.pdf
http://www.ncbi.nlm.nih.gov/pubmed/18043231
> Curr Opin Gastroenterol. 2008 Jan;24(1):38-47.
> Pathogenesis and treatment of Shiga toxin-producing Escherichia coli
> infections.
> Serna A 4th, Boedeker EC.
> Division of Gastroenterology/Hepatology, Department of Internal
> Medicine, University of New Mexico School of Medicine, Albuquerque,
> NM 87131-0001, USA.
> Abstract
> PURPOSE OF REVIEW: Shiga toxin-producing Escherichia coli cause
> hemorrhagic colitis and hemolytic uremic syndrome. We will summarize
> the literature on incidence and outcomes of these infections, and
> then review the pathogenesis to explain the current recommendations
> against antibiotic use and to suggest alternative therapies. RECENT
> FINDINGS: Shiga toxin-producing E. coli continue to be prevalent in
> the industrialized world because of dissemination in food products
> contaminated by ruminant feces. Declines in ground beef-related
> outbreaks have been matched by increased cases related to green
> vegetables. Fifteen percent of patients infected with E. coli
> O157:H7 progress to hemolytic uremic syndrome, but this figure may
> reach 50% if antibiotics are used. Mechanisms for bacteriophage
> induction causing Shiga toxin production, and for Shiga toxin
> dissemination to endothelium in gut, kidney and brain, may explain
> the negative effects of antibiotics and lead to rational therapies.
> Shiga toxin binders were not effective in clinical trials, but more
> avid binding agents may be. Current treatment recommendations are to
> maintain hydration to prevent thrombotic complications. Human
> vaccines are unlikely to be utilized. Cattle vaccines may prove the
> most significant approach to this disease. SUMMARY: Improved
> understanding of Shiga toxin-producing Escherichia coli
> pathophysiology and progression to hemolytic uremic syndrome
> provides the basis for prevention, prophylactic and treatment
> strategies.
> PMID: 18043231 [PubMed - indexed for MEDLINE]
>
http://www.nature.com/nm/journal/v6/n3/abs/nm0300_265.html
E. coli can get on plant foods, too, when there is run-off from fields
with the waste of infected cattle, or when people working the fields
or processing locations have become infected and do not use careful
sanitary measures.
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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