From:
Sukie Crandall
Date: 2010-07-04 04:57:52 UTC
Subject: [ferrethealth] abstract may also apply to another species in genus, domestic ferrets
To: fhl <ferrethealth@yahoogroups.com>
http://www.ncbi.nlm.nih.gov/pubmed/20591155
> Virol J. 2010 Jun 30;7(1):145. [Epub ahead of print]
> Full genome comparison and characterization of avian H10 viruses
> with different pathogenicity in Mink (Mustela vison) reveals genetic
> and functional differences in the non-structural gene.
> Zohari S, Metreveli G, Kiss I, Belak S, Berg M.
> Abstract
> ABSTRACT: BACKGROUND: The unique property of some avian H10 viruses,
> particularly the ability to cause severe disease in mink without
> prior adaptation, enabled our study. Coupled with previous
> experimental data and genetic characterization here we tried to
> investigate the possible influence of different genes on the
> virulence of these H10 avian influenza viruses in mink. RESULTS:
> Phylogenetic analysis revealed a close relationship between the
> viruses studied. Our study also showed that there are no differences
> in receptor specificity or the cleavability of the haemagglutinin
> proteins of these viruses regardless of whether they are of low or
> high pathogenicity in mink. In poly I:C stimulated mink lung cells
> the NS1 protein of influenza A virus showing high pathogenicity in
> mink down regulated the type I interferon promoter activity to a
> greater extent than the NS1 protein of the virus showing low
> pathogenicity in mink. CONCLUSIONS: Differences in pathogenicity and
> virulence in mink between these strains could be related to clear
> amino acid differences in the non structural 1 (NS1) protein. The NS
> gene of mink/84 appears to have contributed to the virulence of the
> virus in mink by helping the virus evade the innate immune responses.
> PMID: 20591155 [PubMed - as supplied by publisher]
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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