From: Sukie Crandall
Date: 2010-07-16 19:11:59 UTC
Subject: [ferrethealth] new abstracts
To: fhl <email@example.com>
> Small Anim Pract. 2010 Jul 12. [Epub ahead of print]
> Successful medical management of lumbar intervertebral disc prolapse=20
> in a ferret.
> Srugo I, Chai O, Yaakov D, Sharon L, Shamir MH.
> Koret School of Veterinary Medicine, Hebrew University of Jerusalem,=20
> Rehovot, Israel.
> Thoracolumbar disc herniation was diagnosed in a two-year-old ferret=20
> using a myelogram followed by a computed tomography scan. The ferret=20
> was paraplegic with no control over urination and defecation.=20
> Conservative treatment that included cage rest and passive range of=20
> motion exercises for three weeks followed by extensive physiotherapy=20
> and hydrotherapy resulted in full recovery two months after the=20
> onset of treatment. Although intervertebral disc disease has been=20
> reported previously in four ferrets, this is the first report in=20
> which a postmyelogram computed tomography was used to demonstrate=20
> the herniated disc, and physiotherapy was used as principal=20
> treatment modality.
> PMID: 20630019 [PubMed - as supplied by publisher]
> J Small Anim Pract. 2010 Jul;51(7):393-6.
> Autochthonous Dirofilaria immitis infection in a ferret with=20
> aberrant larval migration in Europe.
> Moln=E1r V, Paz=E1r P, Rig=F3 D, M=E1th=E9 D, Fok E, Gl=E1vits R, Vajdovi=
> Jacs=F3 O, Balogh L, S=F3s E.
> Veterinary and Conservation Department, Budapest Zoo and Botanical=20
> Garden, Allatkerti krt 6-12, H-1146 Budapest, Hungary.
> A two-year-old male ferret (Mustela putorius furo) was presented to=20
> the Faculty of Veterinary Science, Szent Istv=E1n University, for=20
> investigation of somnolence. Following unsuccessful therapeutic=20
> attempts, the ferret was euthanased and a male Dirofilaria immitis=20
> worm was found in the pulmonary artery and a female D. immitis=20
> specimen in the subdural space of the cranial cavity. To the=20
> authors' knowledge, this is the first European record of D. immitis=20
> infection in a ferret, and the first case in which aberrant larval=20
> migration and consequent central nervous system signs were observed=20
> in a ferret in the course of D. immitis infection.
> PMID: 20626785 [PubMed - in process]
> Physiol Res. 2010;59 Suppl 1:S59-64.
> The electrocardiographic Holter monitoring in experimental=20
> veterinary practice.
> Scheer P, Svoboda P, Sepsi M, Janeckov=E1 K, Doubek J.
> Department of Physiology, Faculty of Veterinary Medicine, University=20
> of Veterinary and Pharmaceutical Science Brno, Brno, Czech Republic.
> The long-term electrocardiographic recording with retrospective=20
> evaluation (Holter system) has been widely used not only in=20
> cardiology, but also in other disciplines of internal medicine and=20
> in pharmaceutical research. The Holter system can be used in mini-
> pig, sheep, dog, cat, rabbit, ferret, and rat. In this paper=20
> hardware, software, and anesthesia requirements are summarized with=20
> respect to the experimental work with various species. As the Holter=20
> systems work in bipolar mode, the use of bipolar leads in sagittal=20
> and transversal planes has been proved to be the most appropriate=20
> because of large amplitude of QRS complex and uncomplicated=20
> consequent automatic analysis of the record. In conclusion, Holter=20
> electrocardiography represents a simple and applicable method for=20
> monitoring the electrical activity of the heart in small animals'=20
> experimental studies.
> PMID: 20626221 [PubMed - in process]
> Ontogenez. 2010 May-Jun;41(3):228-31.
> [Cytogenetic study on the activity of the ferret embryonic genome=20
> before implantation]
> [Article in Russian]
> [No authors listed]
> A cytogenetic study of the activity of the embryonic genome in=20
> ferret (Mustelaputorius) blastocysts during 6 days after their=20
> transition from the oviduct to the uterus has been carried out. It=20
> has been found that the prolongation in the preimplantation period=20
> in the ferret is not accompanied by inhibition of mitosis or=20
> activity in nucleolus organizing regions of inner cell mass cells as=20
> occurs in species having an obligatory delay of implantation=20
> (obligate embryonic diapause). Amitosis of trophoblast cells starts=20
> at the periimplantation stage as in other species that do not have=20
> obligate diapause. The data obtained are consistent with the=20
> hypothesis that the obligatory stage of delayed implantation might=20
> occur in some mammals in different taxonomic groups as a result of=20
> chromosome mutations affecting the genetic control of the chronology=20
> of events (timing) of embryogenesis. Consequently the=20
> characteristics of delayed implantation should be different in=20
> different species.
> PMID: 20583631 [PubMed - in process]
I wonder if this system could be modified for delivery of some nasal=20
meds for ferrets:
> Virol J. 2010 Jun 23;7(1):135. [Epub ahead of print]
> Design, assembly, and validation of a nose-only inhalation exposure=20
> system for studies of aerosolized viable influenza H5N1 virus in=20
> Tuttle RS, Sosna WA, Daniels DE, Hamilton SB, Lednicky JA.
> ABSTRACT: BACKGROUND: The routes by which humans acquire influenza=20
> H5N1 infections have not been fully elucidated. Based on the known=20
> biology of influenza viruses, four modes of transmission are most=20
> likely in humans: aerosol transmission, ingestion of undercooked=20
> contaminated infected poultry, transmission by large droplets and=20
> self-inoculation of the nasal mucosa by contaminated hands. In=20
> preparation of a study to resolve whether H5N1 viruses are=20
> transmissible by aerosol in an animal model that is a surrogate for=20
> humans, an inhalation exposure system for studies of aerosolized=20
> H5N1 viruses in ferrets was designed, assembled, and validated.=20
> Particular attention was paid towards system safety, efficacy of=20
> dissemination, the viability of aerosolized virus, and sampling=20
> methodology. RESULTS: An aerosol generation and delivery system,=20
> referred to as a Nose-Only Bioaerosol Exposure System (NBIES), was=20
> assembled and function tested. The NBIES passed all safety tests,=20
> met expected engineering parameters, required relatively small=20
> quantities of material to obtain the desired aerosol concentrations=20
> of influenza virus, and delivered doses with high-efficacy. Ferrets=20
> withstood a mock exposure trial without signs of stress.=20
> CONCLUSIONS: The NBIES delivers doses of aerosolized influenza=20
> viruses with high efficacy, and uses less starting material than=20
> other similar designs. Influenza H5N1 and H3N2 viruses remain stable=20
> under the conditions used for aerosol generation and sample=20
> collection. The NBIES is qualified for studies of aerosolized H5N1=20
> PMID: 20573226 [PubMed - as supplied by publisher]Free Article
Here is the full article on that piece of equipment:
> Open Dent J. 2010 Apr 29;4:37-47.
> Experimental animal models in periodontology: a review.
> Struillou X, Boutigny H, Soueidan A, Layrolle P.
> Department of Periodontology, Faculty of Dental Surgery, University=20
> of Nantes, 1 Place Alexis Ricordeau, 44042 Nantes, France.
> In periodontal research, animal studies are complementary to in=20
> vitro experiments prior to testing new treatments. Animal models=20
> should make possible the validation of hypotheses and prove the=20
> safety and efficacy of new regenerating approaches using=20
> biomaterials, growth factors or stem cells. A review of the=20
> literature was carried out by using electronic databases (PubMed,=20
> ISI Web of Science). Numerous animal models in different species=20
> such as rats, hamsters, rabbits, ferrets, canines and primates have=20
> been used for modeling human periodontal diseases and treatments.=20
> However, both the anatomy and physiopathology of animals are=20
> different from those of humans, making difficult the evaluation of=20
> new therapies. Experimental models have been developed in order to=20
> reproduce major periodontal diseases (gingivitis, periodontitis),=20
> their pathogenesis and to investigate new surgical techniques. The=20
> aim of this review is to define the most pertinent animal models for=20
> periodontal research depending on the hypothesis and expected results.
> PMID: 20556202 [PubMed - in process]PMCID: PMC2885595Free PMC Article
> Lab Anim (NY). 2010 May;39(5):140-1.
> Ovariohysterectomy in ferrets.
> Eshar D, Wyre NR.
> Moriah Veterinary Clinic, Haifa, Israel.
> Surgical sterilization of ferrets is a relatively common surgical=20
> procedure. It is usually done as a method of contraception and to=20
> prevent diseases associated with the reproductive system. This=20
> column will describe the anatomy, principles, possible complications=20
> and outcomes of surgical ovariohysterectomy in ferrets.
> PMID: 20410897 [PubMed - indexed for MEDLINE]
These other recent ones that are not specific to most ferret health or=20
behavior needs but may interest some here w some in related species:
Sukie (not a vet)
Recommended ferret health links:
all ferret topics:
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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