From:
Sukie Crandall
Date: 2010-08-18 20:20:19 UTC
Subject: [ferrethealth] abstract: amputation and treatment for lymphoma in femur
To: fhl <ferrethealth@yahoogroups.com>
> J Am Vet Med Assoc. 2010 Aug 15;237(4):407-14.
> Diagnosis and treatment of myelo-osteolytic plasmablastic lymphoma=20
> of the femur in a domestic ferret.
> Eshar D, Wyre NR, Griessmayr P, Durham A, Hoots E.
> Department of Clinical Studies, School of Veterinary Medicine,=20
> University of Pennsylvania, Philadelphia, PA 19104.
> Abstract
> Case Description-A 6-year-old 0.82-kg (1.8-lb) spayed female=20
> domestic ferret was evaluated because of a 1-month history of=20
> decreased activity that had progressively worsened over the past=20
> week. The ferret had previously been determined to have=20
> adrenocortical disease and was undergoing medical management for the=20
> associated clinical signs. Clinical Findings-Physical examination=20
> revealed lameness of the right hind limb with evidence of pain=20
> elicited during palpation of the right femur. Results of a CBC=20
> suggested mild anemia, and those of a serum biochemical analysis=20
> indicated a high blood glucose concentration. Radiography of the=20
> limb revealed extensive lysis of the right femur. Cytologic=20
> evaluation of a fine-needle aspirate of the bone lesion revealed a=20
> dominant plasma cell component. Plasma cell neoplasia was suspected=20
> on the basis of these findings. Treatment and Outcome-Radical right=20
> hind limb amputation with mid to caudal hemipelvectomy was=20
> performed. Histologic evaluation of the lesion allowed a diagnosis=20
> of lymphoma with plasmablastic features, and immunohistochemical=20
> testing revealed a few CD79alpha-postive neoplastic cells and rare=20
> BLA36-positive cells. Adjunctive antineoplastic treatment with=20
> systemically administered multidrug chemotherapy was initiated. Six=20
> months after surgery, the ferret was reevaluated, and chemotherapy=20
> was discontinued when results of clinicopathologic tests, whole body=20
> survey radiography, and abdominal ultrasonography suggested no=20
> recurrence of the disease. Clinical Relevance-The ferret appeared to=20
> cope well with radical hind limb amputation, and the=20
> chemotherapeutic protocol used was easy to administer. This=20
> treatment approach might lead to better owner and patient compliance=20
> in other cases of lymphoma in ferrets.
> PMID: 20707751 [PubMed - in process]
Perhaps useful:
> 1. Wiad Parazytol. 2010;56(2):117-24.
> [The spread of nematodes from Toxocara genus in the world] [Article=20
> in Polish]
> Borecka A. Instytut Parazytologii im. W. Stefa=C5=84skiego, Polska=20
> Akademia Nauk, ul. Twarda 51/55, 00-818,
> Twenty seven species belong to the genus Toxocara. Most of the=20
> species infect Carnivora from families: Canidae, Felidae,=20
> Viverridae, Procyonidae, Mustelidae and Herpestidae. The most=20
> widespread species are: T. canis, T. cati and T. vitulorum. The life=20
> cycle of Toxocara spp. is connected with young animals and adults=20
> with the lowered immune response. Three of the Toxocara species: T.=20
> canis, T. cati and T. pteropodis are the aetiological agents of=20
> human toxocariasis. PMID: 20707295 [PubMed - in process]
and as usual there also are some probably less applicable ones in
http://www.ncbi.nlm.nih.gov/pubmed/
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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