From:
Sukie Crandall
Date: 2010-08-24 15:04:04 UTC
Subject: [ferrethealth] abstract (and a definition below)
To: fhl <ferrethealth@yahoogroups.com>
PLoS is the Public Library of Science and all of those articles are
there for free in full. I don't have time to seek out the URL but
those interested can do so on their own.
> PLoS One. 2010 Aug 12;5(8). pii: e12099.
> Viremia Associated with Fatal Outcomes in Ferrets Infected with
> Avian H5N1 Influenza Virus.
> Wang X, Zhao J, Tang S, Ye Z, Hewlett I.
> Lab of Molecular Virology, Division of Emerging and Transfusion
> Transmitted Diseases, Food and Drug Administration, Bethesda,
> Maryland, United States of America.
> Abstract
> Avian H5N1 influenza viruses cause severe disease and high mortality
> in infected humans. However, tissue tropism and underlying
> pathogenesis of H5N1 virus infection in humans needs further
> investigation. The objective of this work was to study viremia,
> tissue tropism and disease pathogenesis of H5N1 virus infection in
> the susceptible ferret animal model. To evaluate the relationship of
> morbidity and mortality with virus loads, we performed studies in
> ferrets infected with the H5N1 strain A/VN/1203/04 to assess
> clinical signs after infection and virus load in lung, brain, ileum,
> nasal turbinate, nasal wash, and blood. We observed that H5N1
> infection in ferrets is characterized by high virus load in the
> brain and and low levels in the ileum using real-time PCR. In
> addition, viral RNA was frequently detected in blood one or two days
> before death and associated with symptoms of diarrhea. Our
> observations further substantiate pathogenicity of H5N1 and further
> indicate that viremia may be a bio-marker for fatal outcomes in H5N1
> infection.
> PMID: 20730085 [PubMed - in process]
part of the definition of viremia from (highly recommended!) _Saunders
Comprehensive Veterinary Dictionary_:
"presence of viruses in the blood...
may be local invasion, proliferation in regional lymph nodes, followed
by primary viremia with dissemination to other tissues...
may be secondary viremia followed by increasing tissue damage and
severe clinical disease sometimes including spread of the virus to the
central nervous system"
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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