From:
Sukie Crandall
Date: 2010-08-31 21:29:16 UTC
Subject: [ferrethealth] abstract
To: fhl <ferrethealth@yahoogroups.com>
http://www.ncbi.nlm.nih.gov/pubmed/20797732
> J Surg Res. 2010 May 22. [Epub ahead of print]
> Analgesic Effect of Bupivacaine Eluting Porcine Small Intestinal
> Submucosa (SIS) in Ferrets Undergoing Acute Abdominal Hernia Defect
> Surgery.
> Johnson BM, Ko JC, Hall PJ, Saunders AT, Lantz GC.
> Department of Veterinary Clinical Sciences, Purdue University, West
> Lafayette, Indiana.
> Abstract
> BACKGROUND: Porcine small intestinal submucosa (SIS) is used as a
> biological implant for abdominal wall hernia repair to facilitate
> wound healing and augment local tissue strength. This prospective,
> randomized, blinded study evaluated local pain control provided by
> bupivacaine adsorbed to SIS for repair of acutely created abdominal
> wall full thickness muscle/fascial defects in ferrets.
> MATERIALS AND METHODS: Eighteen healthy ferrets were randomly and
> equally assigned to three groups: (1) SIS with bupivacaine subjected
> to surgery, (2) SIS with no bupivacaine subjected to surgery, and
> (3) anesthesia only control group. Ferrets in groups 1 and 2 were
> anesthetized with butorphanol and sevoflurane for the surgery.
> Control ferrets were anesthetized in the same fashion for the same
> duration without surgery. Behavior and pain were evaluated in all
> ferrets by behavioral observation, algometer, and palpometer
> measurements, and heart and respiratory rates each obtained before
> surgery and at various intervals for 96 h after surgery. When pain
> reached a predetermined threshold, buprenorphine was used as a
> rescue analgesic. The serum and combined tissue concentrations of
> bupivacaine were analyzed.
> RESULTS: Overall, the palpometer testing was better tolerated in the
> bupivacaine treated SIS group than by the untreated SIS group (P =
> 0.04). There was an observed physiologically significant difference
> in algometer and other palpometer readings as well as heart and
> respiratory rates. All ferrets in the untreated SIS group were
> rescued while 33% of the SIS-bupivacaine groups were rescued (P <
> 0.01). Peak serum concentrations of bupivacaine were in the range of
> 0.7 mug/mL with tissue level below detection levels and no clinical
> signs of toxicity were observed.
> CONCLUSIONS: Bupivacaine adsorbed to SIS provided some degree of
> pain relief over 2-4 days with no clinical adverse effects observed
> in the ferrets.
> PMID: 20797732 [PubMed - as supplied by publisher]
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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