From:
Sukie Crandall
Date: 2010-09-12 22:04:56 UTC
Subject: [ferrethealth] Abstract
To: fhl <ferrethealth@yahoogroups.com>
BEGIN QUOTE
J Infect Dis. 2010 Sep 7. [Epub ahead of print]
Influenza Enhances Susceptibility to Natural Acquisition of and
Disease Due to Streptococcus pneumoniae in Ferrets.
McCullers JA, McAuley JL, Browall S, Iverson AR, Boyd KL, Henriques
Normark B.
Department of Infectious Diseases, St Jude Children's Research
Hospital, Memphis, and 2Department of Pathology, Division of
Comparative Medicine, Vanderbilt University, Nashville, Tennessee;
3Department of Bacteriology, Swedish Institute for Infectious Diseases
Control, Karolinska Institutet, Solna, and 4Department of
Microbiology, Tumor Biology, and Cell Biology, Karolinska Institutet,
Stockholm, Sweden.
Abstract
The role of respiratory viruses in the transmission of Streptococcus
pneumoniae is poorly understood. Key questions, such as which
serotypes are most fit for transmission and disease and whether
influenza virus alters these parameters in a serotype-specific manner,
have not been adequately studied. In a novel model of transmission in
ferrets, we demonstrated that pneumococcal transmission and disease
were enhanced if donors had previously been infected with influenza
virus. Bacterial titers in nasal wash, the incidence of mucosal and
invasive disease, and the percentage of contacts that were infected
all increased. In contact ferrets, viral infection increased their
susceptibility to S. pneumoniae acquisition both in terms of the
percentage infected and the distance over which they could acquire
infection. These influenza-mediated effects on colonization,
transmission, and disease were dependent on the pneumococcal strain.
Overall, these data argue that the relationship between respiratory
viral infections, acquisition of pneumococci, and development of
disease in humans needs further study to be better understood.
PMID: 20822454 [PubMed - as supplied by publisher]
END QUOTE
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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