From:
Sukie Crandall
Date: 2010-09-15 18:20:33 UTC
Subject: [ferrethealth] abstract
To: fhl <ferrethealth@yahoogroups.com>
> Toxicol Pathol. 2010 Sep 13. [Epub ahead of print]
> Nasal Turbinate Enlargement Due to Cartilage and Bone Proliferation:
> A Normal Developmental Finding in Young Ferrets.
> Funk KA, Frantz C, Dyke AS, Ryan PC, Jin H, Kemble G, Dixit R,
> Leininger JR.
> Abstract
> Toxicity studies of intranasally administered, live attenuated
> influenza virus vaccine candidates conducted in male and female
> ferrets led to the microscopic observation of individual differences
> in the size of nasal turbinates, especially in the dorsal aspect of
> the nasal cavity. The association of these enlarged turbinates with
> acute to subacute inflammation, which is sometimes common in ferrets
> given live attenuated influenza virus vaccine candidates, led to
> this detailed microscopic evaluation of turbinate enlargement
> (cartilaginous and osseous thickening, or COT) in control animals
> dosed intranasally with saline. Results of this evaluation led to
> the conclusion that COT is a normal developmental feature of growing
> ferrets, irrespective of inflammation in nasal tissues or
> inflammatory exudate in the nasal cavity.
> PMID: 20837975 [PubMed - as supplied by publisher]
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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