Message Number: FHL12294 | New FHL Archives Search
From: Sukie Crandall
Date: 2010-10-02 04:57:22 UTC
Subject: [ferrethealth] abstract
To: fhl <>

an unusual one to please the pathologists

> J Comp Pathol. 2010 Sep 27. [Epub ahead of print]
> Detection and Molecular Characterization of Mycobacterium celatum as
> a Cause of Splenitis in a Domestic Ferret (Mustela putorius furo).
> Piseddu E, Trotta M, Tortoli E, Avanzi M, Tasca S, Solano-Gallego L.
> Veterinary Diagnostic Laboratory and Hospital 'San Marco', Padua,
> Italy.
> Abstract
> Mycobacterium celatum is a slow growing non-tuberculous
> mycobacterium described mainly as occurring in human patients. Only
> two cases of infection with this pathogen have been reported
> previously in animals. A 5-year-old, neutered male ferret was
> presented with progressive weight loss and muscle atrophy. Pale
> mucous membranes, slight alopecia of the tail and splenomegaly,
> confirmed by abdominal ultrasound, were observed. Fine-needle
> aspirations of the spleen revealed extramedullary haematopoiesis and
> marked macrophage-dominated inflammation associated with
> mycobacterial infection. Ziehl-Neelsen staining demonstrated
> sporadic acid-fast bacilli within macrophages. These organisms were
> identified as M. celatum by microbiological and molecular methods.
> Phylogenetic analysis based on the 16S rDNA gene compared this
> isolate with previously reported strains and demonstrated close
> relatedness to the human strains of M. celatum types 1 and 3. The
> ferret was treated with enrofloxacin, rifampicin and azithromycin,
> resulting in clinical improvement. After 40 days of treatment, the
> spleen was re-evaluated. Cytological evaluation revealed only
> extramedullary haematopoiesis without evidence of infection.
> Discontinuation of therapy was followed by rapid deterioration and
> death.
> PMID: 20880545 [PubMed - as supplied by publisher]

Sukie (not a vet)

Recommended ferret health links:
all ferret topics:

"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)


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