Message Number: FHL12360 | New FHL Archives Search
From: "Lisa Oestereich"
Date: 2010-10-18 17:21:09 UTC
Subject: [ferrethealth] Can Deslorelin cause an increase in blood glucose?
To: <>

[>Glucose (fasted) (mg/dl) 110 65-164
>GLU 262
is scary (The first value you give for it, 10/12.)
>GLU 414.0 mg/dl
that you give for 10/15 is pronounced diabetes.

In ferrets it is possible after insulinoma has been
going on for a while for enough tissue to be
destroyed that diabetes begins.

It looks like this is a ferret who has done that
but is still being medicated for insulinoma
with Prednisolone which will worsen the diabetes.
-- Moderator (SDC)]

I am posting this for a one-finger typist who currently has a very ill
ferret. She thinks the Deslorelin implant they had put in the ferret a
month ago is causing a severe increase in the ferret's glucose (there
are other problems with the blood work/organs as well). They want the
vet to remove the implant asap, but wanted to post the info here, for
input, as well.

[I don't know how much actual research there is
on this question but I do know that the OPPOSITE
has been seen a lot with insulinoma coming better
under control when the implant brings the adrenal
disease under control and have discussed this with
Dr. Robert Wagner of U. Pittsburgh. That happened
with both of our ferrets who had both, BTW, with
their insulinoma coming better under control with
Suprelorin for their adrenals. We actually had to reduce
the dose of Prednisolone for one of them. This does
not appear to be a direct effect but secondary and there
is no evidence that the correction of the adrenal disease
through use of Suprelorin can raise blood glucose to
unhealthy levels.
-- Moderator (SDC)]

This particular vet made a comment that the prednisilone they were
giving their other ferrets (the kind that doesn't need to be
refrigerated, but also has alcohol in it) could not be absorbed by a
ferret and that they should only use the compounded, refrigerated, no
alcohol prednisilone. I would like to know if this is a true statement
because I know many people who use that form of pred.

[I think that the person is confused and needs to
talk more with the vet. We use the non-refrigerated
generic prednisolone with fine results. I suspect the
vet said that Prednisone is hard for ferrets to utilize
when the liver is at all compromised so Prednisolone
should be used and it can be compounded. If so,
that is an accurate statement but it does not need
to be in the compounded form.

Remember: NEVER give Prenisolone with diabetes!
-- Moderator (SDC)]

Also, are there any risks to removing the implant and how long will it
take for the effects of the implant to be out of his system?

Please let me know if you need additional information and I will get it
from the owner and post it.


Peanut, 7 years old, male, 2.3 lbs, neutered

10/11/10 - vet visit, temp 102.3

Weakness in hind legs. Glucose 234, possibly some dehydration. Pred
prescribed at .2 cc once daily


Temp: 99.6

Owner very concerned, ferret lethargic. Owner is concerned implant is
causing problem. Not walking at all today. Weak and dehydrated,
responsive but depressed. Reflexes intact, enlarged spleen as before.
Tentative diagnosis: kidney disease vs. infection vs cancer.

Blood work: 12 october 3:52 PM

ALB 3.7

ALP 69

ALT 232

AMY 33

TBIL 0.3

BUN 98

CA 16.0

PHOS 7.5

CRE 2.3

GLU 262

NA 147

K+ 4.8

TP 7.0

GLOB 3.3

Hem 2+ LIP 2+ 1CT 0

WBC 14.06

LYM 0.14

MON 1.11

NEU 12.81

LY% 1.0

MO% 7.9

NE% 91.1

RBC 10.39

HGB 15.6

HCT 43.30

MCV 42

MCH 15.0

MCHC 36.1

RDWc 18.7

PLT 39

PCT 0.03

MPV 7.9

PDWc 36.1

10/15/10 - ferret not doing any better. Stools are thick apple butter
with some mucous. Owner has to move him to litter box, cannot use back
legs. No coughing, sneezing, vomiting diarrhea. Diet: chicken baby

Blood Work 10-15-10, 1:36 PM

ALB 3.9 g/dl

ALP 83.0 U/L

ALT 234 U/L

AMY 38.0 U/L

TBIL 0.4 MG/dl

BUN 82.0 mg/dl

CA 16.0 mg/dl

PHOS 6.2mg/dl

CRE 3.3 mg/dl

GLU 414.0 mg/dl

NA+ 146.0 mmol/L

K+ 4.6 mmol/L

TP 6.5 g/dl

GLOB 2.6 g/dl

Lip 2+


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