From: "Karen McCabe"
Date: 2010-11-05 07:01:45 UTC
Subject: [ferrethealth] Re: tufts protocol
--- In firstname.lastname@example.org, "marci1111" <marci1111@...> wrote:
> I'm just wondering if anyone has experience with the Tufts Protocol on an elderly ferret. I'm also interested in hearing especially from anyone that has had a ferret on prednislone for insulomia, prior to starting the chemo. Please let me know if you finished the 27 week course and if it was successful in remission.
My ferret Jacob was diagnosed with lymphoma in late July. He presented with a grossly enlarged mesenteric node but no tumors. He was given high dose pred for one week, in which time the node returned to normal size. He was then started on the Tuft's Protocol. He did well until week three, when Cytoxan was given. Three days later Jacob suddenly developed a large intestinal tumor. In some cases, secondary cancers have been reported to occur during and following treatment with Cytoxan. As my vet explained, this was what occurred with Jacob. There was nothing that could be done, we had to euthanize. Jacob was only three years old, so not elderly, but this adverse effect can occur in any ferret of any age and is something anyone considering this treatment should be aware of.
[This statement interests me but I could not find
any research articles indicating that cytoxin
can at all cause new tumors during the initial
disease that is under treatment so am wondering
if perhaps it may not be as strong in some ways as
the chemo types used before it so maybe hidden
existing tumors are allowed to grow enough to show
themselves due to reduced impact compared to earlier
drugs, or what other possible mechanism may be
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