From:
"Karen McCabe"
Date: 2010-11-05 16:27:24 UTC
Subject: [ferrethealth] Re: tufts protocol
To: ferrethealth@yahoogroups.com
--- In ferrethealth@yahoogroups.com, "Karen McCabe" <karenmc@...> wrote:
>
In some cases, secondary cancers have been reported to occur during and following treatment with Cytoxan.
>
> Karen McCabe
> [This statement interests me but I could not find
> any research articles indicating that cytoxin
> can at all cause new tumors during the initial
> disease that is under treatment so am wondering
> if perhaps it may not be as strong in some ways as
> the chemo types used before it so maybe hidden
> existing tumors are allowed to grow enough to show
> themselves due to reduced impact compared to earlier
> drugs, or what other possible mechanism may be
> present?
> -- Moderator]
>
"Cyclophosphamide is a cytotoxic immunosuppressive and anticancer drug that has been used to treat a large variety of human disorders. It alkylates and phosphorylates important cellular macromolecules and preferentially kills cells that are rapidly dividing, but it is also effective against nonproliferating cells.1 The drug is critical to the effectiveness of many cancer-treatment regimens, in which it is often combined with other antitumor agents. Cyclophosphamide is also associated with serious adverse effects, including secondary cancer, severe leukopenia with infection, and hemorrhagic cystitis."
To see more you will need to either subscribe or purchase the article, here....
http://www.nejm.org/doi/pdf/10.1056/NEJM198402163100710
Karen McCabe
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