Message Number: FHL12624 | New FHL Archives Search
From: Sukie Crandall
Date: 2010-12-19 17:23:34 UTC
Subject: [ferrethealth] ECE: I was looking up treatments for someone
To: fhl <>

There simply do not seem to be any new treatments to help with ECE in
ferrets so I went searching on other enteric coronaviruses in other
animals and was left wondering if this Lactobacillus approach might be
worthwhile trying in ferrets with ECE though I don't know how vets
would get the specific strains of Lactobacillus. Perhaps in those
ferrets who are NOT getting antibiotics (and maybe some of those who
are) there might be more commonly found Lactobacillus strains that
might help?

> Trop Anim Health Prod. 2010 Dec;42(8):1855-60. Epub 2010 Jul 10.
> Putative probiotic Lactobacillus spp. from porcine gastrointestinal
> tract inhibit transmissible gastroenteritis coronavirus and enteric
> bacterial pathogens.
> Kumar RV, Seo BJ, Mun MR, Kim CJ, Lee I, Kim H, Park YH.
> Department of Applied Microbiology and Biotechnology, Yeungnam
> University, Kyongsan, Kyeongbuk, 712-749, South Korea.
> Abstract
> A total of 310 bacterial strains isolated from the porcine
> gastrointestinal tract were tested for their activity against
> transmissible gastroenteritis (TGE) coronavirus and other enteric
> pathogens. Based on activity, the strains Probio-38 and Probio-37
> were selected as potential probiotics and identified as
> Lactobacillus plantarum Probio-38 and Lactobacillus salivarius
> Probio-37 respectively by 16S rRNA gene sequencing. Supernatants of
> these strains inhibited TGE coronavirus in vitro in ST cells,
> without any cytopathic effect even after 72 h of incubation. Both
> the strains exhibited high survival in synthetic gastric juice. The
> strains were resistant to 5% porcine bile and exhibited
> antimicrobial activity against all the 13 enteric bacterial
> pathogens tested. These strains also exhibited resistance to most of
> the antibiotics analyzed. The inhibition of transmissible
> gastroenteritis coronavirus and enteric bacterial pathogens as well
> as the bile tolerance, high survival in gastric juice, and the
> antibiotic resistance indicate that the two isolated bacterial
> strains are ideal probiotic candidates for animal application after
> proper in vivo experiments.
> PMID: 20623187 [PubMed - in process]

The key things for ECE appear to remain: hydration, hydration,
hydration (so sub cu and even IV may be needed), isolation for at
least 8 months, bland and cooked foods such as second stage meat baby
foods, avoidance of causes of secondary infections but treating when
they are caught (Be careful to not use antibiotics when they are not
needed to avoid creating other problems like antibiotic resistant
infections so let the vet decide.), treating existing problems that
have been exacerbated, and patience and acceptance of what you simply
can not change.
remains as the gold standard.

Sukie (not a vet)

Recommended ferret health links:
all ferret topics:

"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)


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