From: Sukie Crandall
Date: 2011-02-25 21:29:00 UTC
Subject: [ferrethealth] abstract: new species of mink cornavirus
To: fhl <firstname.lastname@example.org>
> J Gen Virol. 2011 Feb 23. [Epub ahead of print]
> Molecular characterization of a new alphacoronavirus species associated with mink epizootic catarrhal gastroenteritis.
> Vlasova AN, Halpin R, Wang S, Ghedin E, Spiro DJ, Saif LJ.
> Food Animal Health Research Program, OARDC, Ohio State University;
> A coronavirus (CoV) previously shown to be associated with catarrhal gastroenteritis in mink (Mustela vison) was identified by electron microscopy (EM) in mink feces from two fur farms in Wisconsin and Minnesota in 1998. We initially used our pancorona and genus-specific RT-PCR assays and demonstrated that the newly discovered mink CoVs (MCoVs) are alphacoronaviruses. Subsequently, using a random RT-PCR approach, we generated full-genomic sequences and further confirmed that phylogenetically MCoVs belong to alphacoronavirus genus with the closest relatedness to the recently identified but only partially sequenced (fragments of polymerase, and full-length spike, 3c, envelope, nucleoprotein, membrane, 3x and 7b genes) ferret enteric and systemic coronavirus (FRECV and FRSCV). Molecular data presented in this study provides the first genetic evidence for a new coronavirus associated with epizootic catarrhal gastroenteritis outbreaks in mink and demonstrates that MCoVs possess
high genomic variability and relatively low overall nucleotide sequence identities (91.7%) between contemporary strains. Additionally, the new MCoVs appear to be phylogenetically distant from human (229E and NL63) and other alphacoronaviruses and do not belong to alphacoronavirus 1 species. We propose that with the partially sequenced FRECV, they comprise a new species within the alphacoronavirus genus.
> PMID: 21346029 [PubMed - as supplied by publisher]
Sukie (not a vet)
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(2010, Steve Crandall)
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