Message Number: FHL12919 | New FHL Archives Search
From: "SukieC"
Date: 2011-02-26 00:23:06 UTC
Subject: [ferrethealth] Re:Urine pH

Okay, I did a little looking up and found these things:
The typical cause of cystine stones is the inability to
reabsorb cystine and sometimes some other amino acids.
Cystine is the amino acid which precipitates out most easily
which is why that is the stone content. So, concentration
is the usual core event due to that kidney defect, at least
that seems to be the latest thinking. (But see the next paragraph, too)

On the other hand, a large number of the experiments done
in labs on this topic got the urine or urine-substitute
solution by using a high pH (10) and then to get precipitation
they lowered the pH to 5. So, I guess that echoes the
question: if something else lowers the urine pH even without
a defect at what pH would whatever amount of cystine that
is not absorbed by a normal kidney or a diseased kidney
(without that genetic defect) have a chance of precipitating out
just based on plain old chemistry?

Another question: How much cystine is not absorbed by healthy
kidneys and do diseased kidneys have reduced amino acid
absorbing abilities?

And a final question: could overfed ferrets with high protein
diets -- so a high amino acid intake -- and compromised kidneys
perhaps be at risk IF the other questions have certain answers
even without that genetic defect and at what pH in that case?


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