Date: 2011-02-27 18:41:01 UTC
Subject: [ferrethealth] Re: Cystine stones/urine pH
Simply put ferrets with normal kidneys will absorb the
amino acid cystine in the proximal kidney tubular cells.
Thus no cystine goes into the urine. Therefore regardless
of how low the pH of the urine is, cystine stones can not form.
Only ferrets with a genetic defect in the proximal tubular cells
have cystine in the urine and can develop cystine stones.
Thus it is not the urine pH that causes cystine stones, it is the kidney
defect. In ferrets with this some what rare kidney problem, increasing
the urine pH will increase the solubility of cystine and help prevent
from forming stones.
Hope that answers your questions,
Jerry Murray, DVM
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