From: Sukie Crandall
Date: 2011-02-27 19:03:57 UTC
Subject: Re: [ferrethealth] Re:Melatonin confusion
On Feb 27, 2011, at 1:46 PM, AFERRETVET@cs.com wrote:
> Hi Sukie
> The article about transforming growth factor alpha in
> sheep and ferrets is about signaling and growth factors.
> It is not about the hormonal regulation of the hair follicles
> or the adrenal hormones.
> Hope that clears up the confusion,
> Jerry Murray, DVM
That is a pathway which allows ferrets to regrow fur but does NOT help treat adrenal disease.
The other pathway does affect adrenal hormones.
I guess that my post may have been unclear. There have been a number of people on the Ferret Mailing List recently who have been acting as if adrenal disease in ferrets given melatonin can be monitored by how well the fur regrows. Nope. That is not the case because melatonin also acts through this other pathway, so the fur regrowth with melatonin should NOT be assumed to mean that good control of the adrenal disease has been achieved by using melatonin.
I like melatonin, especially the implants, in conjunction with either Suprelorin or Lurpon Depot, actually, but want people to realize that making assumptions about the state of the adrenal disease from fur regrowth after giving melatonin is not logical because of that second pathway for fur regrowth.
Treatments for adrenal disease also became part of that discussion on the FML.
Sukie (not a vet)
Recommended ferret health links:
all ferret topics:
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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