Message Number: FHL13083 | New FHL Archives Search
From: Sukie Crandall
Date: 2011-03-31 19:53:55 UTC
Subject: [ferrethealth] a mink genetic study which may be worth considering in case it affects any ferret colors such as silvers
To: fg <>, fhl <>

For Ferret-Genetics members:
The part that says "Mustela vison Schreber, 1777" is the genus, species, namer of the animal, and the year named -- which typically also involves a specimen or partial specimen of the animal in a major museum or university and detailed description so that later animals given new names can be compared to see if they might just be the same in which case those later names are lost.

For Ferret-Genetics and Ferret Health List members:
Anyway, this might indicate that there may be health reasons to not breed ferrets who MIGHT carry similar alleles together.

For Ferret Health List members:
It may also mean that vets might want to see if ferrets of certain colorations have similar alterations and what they might mean for ferret health if present.

> Genetika. 2011 Jan;47(1):87-94.
> [Effect of mutations affecting coat color on the blood lymphocyte structure in the American mink (Mustela vison Schreber, 1777)].
> [Article in Russian]
> [No authors listed]
> Abstract
> American minks with different genotypes containing the Aleutian coat color allele in the homozygous state, including the single recessive Aleutian (a/a); double recessive sapphire (a/a p/p) and lavender (m/m a/a); triple recessive violet (m/m a/a p/p); and dominant-recessive cross sapphire (S/+ a/a p/p), sapphire leopard (S(K)/+ a/a p/p), and shadow sapphire (S(H)/+ a/a p/p) minks, as well as American minks without the Aleutian allele, including the standard (+/+); single recessive silver-blue (p/p) and hedlund-white (h/h); double recessive pearl (k/k p/p), Finnish topaz (t(S)/t(S) b/b); incompletely dominant royal silver (S(R)/+), standard leopard (S(K)/+), and black crystal (C(R)/+); and dominant-recessive snowy topaz (C(R)/+ t(S)/t(S) b/b) and Kujtezhy-spotted (S(K)/+ b/b) minks have been studied. Homozygosity for the a allele has been found to disturb the subcellular structure of leukocyte, namely the formation of abnormally large granules.
> PMID: 21446186 [PubMed - in process]

See also in beige mice:

In humans giant granules are involved in Chediak-Higashi
which is incredibly rare and also involves a tendency toward
easily getting infections and some other serious problems:
> Chediak-Higashi syndrome is also characterized by a condition called oculocutaneous albinism, which causes abnormally light coloring (pigmentation) of the skin, hair, and eyes. Affected individuals typically have fair skin and light-colored hair, often with a metallic sheen. Oculocutaneous albinism also causes vision problems such as reduced sharpness; rapid, involuntary eye movements (nystagmus); and increased sensitivity to light (photophobia).
> Many people with Chediak-Higashi syndrome have problems with blood clotting (coagulation) that lead to easy bruising and abnormal bleeding. In adulthood, this condition can also affect the nervous system, causing weakness, clumsiness, difficulty with walking, and seizures.

Some of the mink pastels also have brain differences:

> 1. Genetika. 2009 Dec;45(12):1641-5.
> [Effects of monorecessive and double recessive mutations affecting coat color on
> the monoamine content of the brain of the American mink (Mustela vison Schreber,
> 1777)].
> [Article in Russian]
> Trapezov OV, Trapezova LI, alekhina TA, Klochkov DV, Ivanov IuN.
> The effects of mutations affecting the coat color on the dopamine, noradrenaline,
> and serotonin contents of the hypothalamus and brainstem of the American mink
> have been studied. The sample comprised standard (+/+) and mutant minks,
> including the monorecessive pastel (b/b), silver-blue (p/p), and white hedlund
> (h/h) and the combination double recessive sapphire (a/a p/p) and pearl (k/k p/p)
> ones. The dopamine content of the brainstem of the monorecessive pastel (b/b) and
> silver-blue (p/p) minks has been found to be higher than in standard (+/+) minks.
> Conversely, the homozigosity for two coat color loci in double recessive pearl
> minks (k/k p/p) significantly decreases the noradrenaline and serotonin contents
> of the hypothalamus. In addition, monorecessive and double recessive minks differ
> from each other in the serotonin contents of the midbrain and medulla.
> PMID: 20198975 [PubMed - indexed for MEDLINE]

Sukie (not a vet)

Recommended ferret health links:
all ferret topics:

"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)


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