From:
"Tressie"
Date: 2011-04-19 22:29:15 UTC
Subject: [ferrethealth] Re: Non-regenerative Anemia and Reaction to Shots
To: ferrethealth@yahoogroups.com
Hi Susan,
There does appear to be a connection between vaccine reaction and subsequen=
t non-regenerative anemia from observations in veterinary clinical practice=
. Here are some links to articles written by veterinarians that discuss th=
is in animal companions other than ferrets, including specific breeds of do=
gs that appear to be more prone to developing anemia:
http://www.holisticpetvet.com/index.php/news/post-vaccine/
http://www.pet-informed-veterinary-advice-online.com/vaccine-side-effects.h=
tml
http://www.modernveterinarytherapeutics.com/vaccination%20protocols%20for%2=
0dogs%20predisposed%20to%20vaccine%20reactions.pdf
And following is a recent case study of a ferret developing severe anemia a=
nd subsequent successful treatment. This is the first known case of PRCA i=
n a ferret.
Immune-mediated pure red cell aplasia in a domestic ferret
Shachar Malka, dvm, dabvp; Michelle G. Hawkins, vmd, dabvp; Shanon M. Zabol=
otzky, dvm, dacvp;
Elizabeth B. Mitchell, ma, dvm, dabvp; Sean D. Owens, dvm, dacvp
Case Description=97An 8-month-old spayed female domestic ferret (Mustela pu=
torius furo)was referred for examination to determine the cause of lethargy=
and severe anemia.
Clinical Findings=97Initial examination revealed that the ferret was lethar=
gic but with appropriate mentation. The only other abnormal findings were s=
evere pallor of the mucous membranes, nasal planum, and skin and a PCV of 8=
%. Pure red cell aplasia(PRCA) was diagnosed on the basis of cytologic eval=
uation of a bone marrow biopsy
specimen.
Treatment and Outcome=97Medical treatment included blood transfusions, IM a=
dministration of iron dextran, oral administration of antimicrobials and ga=
strointestinal tract protectants,
and SC administration of erythropoietin. Once PRCA was diagnosed, the ferre=
t was orally administered prednisone, cyclosporine, and azathioprine. Nine =
months after onset of treatment, the PRCA was in remission and the ferret w=
as doing well. Immunosuppressive
treatment was discontinued at 14 months after onset of treatment, and 36 mo=
nths after initial examination, the ferret appeared to be healthy.
Clinical Relevance=97It is important that PRCA be considered as a different=
ial diagnosis for a ferret with severe anemia. Prolonged immunosuppressive =
treatment was successful in the ferret described here. (J Am Vet Med Assoc =
2010;237:695=96700).
Link to this article: http://www.2ndchance.info/ferretanemia-PRCA.pdf
Note the 'Clinical Relevance'in the last paragraph!
Tressie
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