From:
Sukie Crandall
Date: 2011-04-22 16:39:11 UTC
Subject: [ferrethealth] abstract
To: fhl <ferrethealth@yahoogroups.com>
Usually the ferret influenza study ones don't contain interesting new info,=
but this one does:
> J Gen Virol. 2011 Apr 20. [Epub ahead of print]
> Lack of transmission of a human influenza virus with avian receptor speci=
ficity between ferrets is not due to decreased virus shedding, but rather a=
lower infectivity in vivo.
> Roberts KL, Shelton H, Scull MA, Pickles RJ, Barclay WS.
> Source
> Imperial College London.
> Abstract
> Influenza virus attaches to host cells by sialic acid (SA). Human influen=
za viruses show preferential affinity for =CE=B12,6 linked SA whereas avian=
influenza viruses bind =CE=B12,3 linked SA. Mutation of the haemagglutinin=
receptor binding site of a human H3N2 influenza A virus to switch binding =
to =CE=B12,3 SA did not abrogate infection of ferrets but prevented transmi=
ssion even in a co-housed model. The mutant virus was shed from the noses o=
f ferrets directly inoculated with virus in the same amounts and for the sa=
me length of time as wild type virus. Mutant virus infection was localised =
to the same anatomical regions of the upper respiratory tract of directly i=
noculated animals. Interestingly, wild type virus was more readily neutrali=
zed than the mutant virus in vitro by ferret nasal washes containing mucus.=
Moreover after inoculation of equal doses, mutant virus grew poorly in ex =
vivo ferret nasal turbinate tissue compared to wild type virus. The dose of=
mutant virus required to establish infection in the directly inoculated fe=
rrets was 40 fold higher than for wild type virus. We conclude that minimum=
infectious dose is a predictor of virus transmissibility. We suggest that =
as virus passes from one host to another through stringent environmental co=
nditions, viruses with a preference for =CE=B12,3 linked SA are unlikely to=
inoculate a new mammalian host in sufficient quantities to initiate a prod=
uctive infection.
>
> PMID: 21508186
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
------------------------------------
Yahoo! Groups Links
<*> To visit your group on the web, go to:
http://groups.yahoo.com/group/ferrethealth/
<*> Your email settings:
Individual Email | Traditional
<*> To change settings online go to:
http://groups.yahoo.com/group/ferrethealth/join
(Yahoo! ID required)
<*> To change settings via email:
ferrethealth-digest@yahoogroups.com
ferrethealth-fullfeatured@yahoogroups.com
<*> To unsubscribe from this group, send an email to:
ferrethealth-unsubscribe@yahoogroups.com
<*> Your use of Yahoo! Groups is subject to:
http://docs.yahoo.com/info/terms/