Message Number: FHL13165 | New FHL Archives Search
From: Sukie Crandall
Date: 2011-04-22 16:39:11 UTC
Subject: [ferrethealth] abstract
To: fhl <>

Usually the ferret influenza study ones don't contain interesting new info,=
but this one does:

> J Gen Virol. 2011 Apr 20. [Epub ahead of print]
> Lack of transmission of a human influenza virus with avian receptor speci=
ficity between ferrets is not due to decreased virus shedding, but rather a=
lower infectivity in vivo.
> Roberts KL, Shelton H, Scull MA, Pickles RJ, Barclay WS.
> Source
> Imperial College London.
> Abstract
> Influenza virus attaches to host cells by sialic acid (SA). Human influen=
za viruses show preferential affinity for =CE=B12,6 linked SA whereas avian=
influenza viruses bind =CE=B12,3 linked SA. Mutation of the haemagglutinin=
receptor binding site of a human H3N2 influenza A virus to switch binding =
to =CE=B12,3 SA did not abrogate infection of ferrets but prevented transmi=
ssion even in a co-housed model. The mutant virus was shed from the noses o=
f ferrets directly inoculated with virus in the same amounts and for the sa=
me length of time as wild type virus. Mutant virus infection was localised =
to the same anatomical regions of the upper respiratory tract of directly i=
noculated animals. Interestingly, wild type virus was more readily neutrali=
zed than the mutant virus in vitro by ferret nasal washes containing mucus.=
Moreover after inoculation of equal doses, mutant virus grew poorly in ex =
vivo ferret nasal turbinate tissue compared to wild type virus. The dose of=
mutant virus required to establish infection in the directly inoculated fe=
rrets was 40 fold higher than for wild type virus. We conclude that minimum=
infectious dose is a predictor of virus transmissibility. We suggest that =
as virus passes from one host to another through stringent environmental co=
nditions, viruses with a preference for =CE=B12,3 linked SA are unlikely to=
inoculate a new mammalian host in sufficient quantities to initiate a prod=
uctive infection.
> PMID: 21508186

Sukie (not a vet)

Recommended ferret health links:
all ferret topics:

"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)


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