Message Number: FHL13202 | New FHL Archives Search
From: "meryl"
Date: 2011-04-29 18:20:08 UTC
Subject: [ferrethealth] Re: Flagyl Compounding

I recently took in a ferret (owner had to place for personal reasons)who had previously been seen and diagnosed by my veterinarian as having insulinoma and helicobacter (grinding teeth really badly). The ferret had been on transdermal forms of both prednisolone and metronidazole (with his previous owner)for some time. The pred obviously works transdermally (I've been kind of skeptical myself about this form) since his bg has stayed up on it. Owner had difficulty giving oral forms of both drugs.

The flagyl/metronidazole also seems to be doing the trick since he rarely grinds his teeth now after a month in my care. Must admit I had my doubts initially on how this would work. The only change is having to put the finger part of a latex glove (I snip two off a glove each morning)on my index finger for each application to the inside of the pinna of each ear. Zeno gets each med applied/spread (first squeezed onto the gloved finger)separately to inside of each pinna, and it seems pretty easy. The pred is more difficult since he gets 0.02ml and my eyesight is not what it was with the tiny markings on the syringes. The flagyl is .05ml and is a snap to measure out and apply. As dispensed the flagyl/metronidazole is 250 mg/ml and the prednisolone is 100mg/ml. It comes to the vet via a compounding pharmacy. I assume the concentrations are high because you can't put big globs of the gel on the ear and have it be absorbed easily. Don't know if these are standard concentrations di
spensed by the pharmacy or if the vet can order particular concentrations. Don't know how much testing has been done on the absorption of other meds transdermally, but these two drugs seem to work in that formulation.



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