Message Number: FHL13293 | New FHL Archives Search
From: "SukieC"
Date: 2011-05-25 01:13:27 UTC
Subject: [ferrethealth] Re: Pyogranulomatous Steatitis

DIM is among the things which appear to be more consistent with the data.

Working from the _Saunders Comprehensive Veterinary Dictionary_:

pyogranulomatous steatitis

Steatitis means inflammation of fatty tissue (any cause)

Pyogranuloma is
"an inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells.

Nutritional steatis is the disorder associated with the dietary lipids problem which Tressie mentioned, as I recall.

Pyogranulomatous steatitis is part of what we encountered with a ferret who had DIM as well as the fascia and muscle being destroyed IF I recall right. Her's began as a sudden extreme swelling behind on rear leg, BTW.

Vet Pathol. 2007 Jan;44(1):25-38.

Myofasciitis in the domestic ferret.

Garner MM, Ramsell K, Schoemaker NJ, Sidor IF, Nordhausen RW, Bolin S, Evermann
JF, Kiupel M.

Northwest ZooPath, Monroe, WA, USA.

Since late 2003, an inflammatory disease of muscle and fascia has been diagnosed
in several ferrets at Northwest ZooPath, and this report describes the condition
in 17 ferrets. It is a disease of young ferrets, characterized by rapid onset of
clinical signs, high fever, neutrophilic leukocytosis, treatment failure, and
death (or euthanasia). Gross lesions include atrophy of skeletal muscle; red and
white mottling and dilatation of the esophagus; and splenomegaly. Histologically,
moderate to severe suppurative to pyogranulomatous inflammation is in the
skeletal muscle and the fascia at multiple sites, including esophagus, heart,
limbs, body wall, head, and lumbar regions. Myeloid hyperplasia of spleen and/or
bone marrow also is a prominent feature. Ultrastructural lesions include
mitochondrial swelling, intracellular edema, disruption of myofibrils and Z
bands. Bacterial and viral cultures, electron microscopy, immunohistochemistry,
and polymerase chain reaction were negative for a variety of infectious agents.
The clinical presentation and distribution of lesions suggests that polymyositis
in domestic ferrets is likely a distinct entity. The etiopathogenesis if this
condition is not known.

PMID: 17197621 [PubMed - indexed for MEDLINE]

That entire article is available for free in:


DIM appears to be an immune-mediated disease which may involve a genetic vulnerability and some sort of trigger. For example, a type of medication that no longer exists was thought to possibly be the trigger for the ones earlier with that.

These may also be helpful to know about but the locations differ with at least some of these:

Sukie (not a vet)

Recommended ferret health links:
all ferret topics:

"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)


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