From:
Sukie Crandall
Date: 2011-06-25 20:58:29 UTC
Subject: [ferrethealth] abstracts
To: FML List <ferret-l@LISTSERV.FERRETMAILINGLIST.ORG>, fhl <ferrethealth@yahoogroups.com>
http://www.ncbi.nlm.nih.gov/pubmed/21696122
> J Vet Dent. 2011 Spring;28(1):8-15.
> Oral examination results in rescued ferrets: clinical findings.
> Eroshin VV, Reiter AM, Rosenthal K, Fordham M, Latney L, Brown S, Lewis JR.
> Source
> Matthew J. Ryan Veterinary Hospital of the University of Pennsylvania, Philadelphia, PA 19104-6010, USA.
> Abstract
> Ferrets have increased in popularity as pets, and a growing number are seen in companion animal practice. Domestic ferrets are commonly used as animal models for research of human oral conditions. The present study evaluated the prevalence of oral pathology in rescued ferrets which - to the authors' knowledge - has not yet been described in the scientific literature. Conscious oral examination was performed on 63 ferrets, of which 49 underwent general anesthesia for further examination. The most common clinical findings included malocclusion of mandibular second incisor teeth (95.2%); extrusion of canine teeth (93.7%); and abrasion and attrition of teeth (76.2%). Tooth fractures were exclusively associated with canine teeth and found in 31.7% of ferrets. Pulp exposure was confirmed in 60.0% of fractured teeth. [ Sukie Note: that is in about 19% of the total number of ferrets when you multiple 31.7% by 60%] The normal gingival sulcus depth measured < 0.5-mm in 87.8% of anesthetized ferrets. Clinical evidence of periodontal disease was present in 65.3% of anesthetized ferrets (gingivitis or probing depths > 0.5-mm), however advanced periodontal disease (i.e. periodontal pockets > 2-mm or stage 3 furcation exposure) was not found upon clinical examination. There was no evidence of tooth resorption, dental caries, stomatitis, or oral tumors in the examined group of ferrets.
>
> PMID: 21696122 [PubMed - in process]
for those in Australasia:
> Vaccine. 2011 Jun 18. [Epub ahead of print]
> A recombinant Hendra virus G glycoprotein-based subunit vaccine protects ferrets from lethal Hendra virus challenge.
> Pallister J, Middleton D, Wang LF, Klein R, Haining J, Robinson R, Yamada M, White J,Payne J, Feng YR, Chan YP, Broder CC.
> Source
> CSIRO Livestock Industries, Australian Animal Health Laboratory, 5 Portarlington Road, Geelong, VIC, 3220, Australia.
> Abstract
> The henipaviruses, Hendra virus (HeV) and Nipah virus (NiV), are two deadly zoonotic viruses for which no vaccines or therapeutics have yet been approved for human or livestock use. In 14 outbreaks since 1994 HeV has been responsible for multiple fatalities in horses and humans, with all known human infections resulting from close contact with infected horses. A vaccine that prevents virus shedding in infected horses could interrupt the chain of transmission to humans and therefore prevent HeV disease in both. Here we characterise HeV infection in a ferret model and show that it closely mirrors the disease seen in humans and horses with induction of systemic vasculitis, including involvement of the pulmonary and central nervous systems. This model of HeV infection in the ferret was used to assess the immunogenicity and protective efficacy of a subunit vaccine based on a recombinant soluble version of the HeV attachment glycoprotein G (HeVsG), adjuvanted with CpG. We report that ferrets vaccinated with a 100μg, 20μg or 4μg dose of HeVsG remained free of clinical signs of HeV infection following a challenge with 5000 TCID(50) of HeV. In addition, and of considerable importance, no evidence of virus or viral genome was detected in any tissues or body fluids in any ferret in the 100 and 20μg groups, while genome was detected in the nasal washes only of one animal in the 4μg group. Together, our findings indicate that 100μg or 20μg doses of HeVsG vaccine can completely prevent a productive HeV infection in the ferret, suggesting that vaccination to prevent the infection and shedding of HeV is possible.
>
> Copyright © 2011. Published by Elsevier Ltd.
>
> PMID: 21689706 [PubMed - as supplied by publisher]
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
On change for its own sake: "You can go really fast if you just jump off the cliff."
(2010, Steve Crandall)
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