Message Number: FHL13816 | New FHL Archives Search

From: Sukie Crandall
Date: 2011-08-17 21:22:25 UTC
Subject: [ferrethealth] abstracts: multiple endocrinological and more; pasturella; Influenza B; spinal cord injury
To: fhl <ferrethealth@yahoogroups.com>

In cat studies the things can can effect diabetes rates are gender, breed, but especially obesity and lack of exercise really worsen the risk level, so in case that might be relevant here that has now been mentioned:

http://www.ncbi.nlm.nih.gov/pubmed/21838985

> J Am Assoc Lab Anim Sci. 2011;50(4):531-5.
> Diabetic Ketoacidosis with Concurrent Pancreatitis, Pancreatic β Islet Cell Tumor, and Adrenal Disease in an Obese Ferret (Mustela putorius furo).
> Phair KA, Carpenter JW, Schermerhorn T, Ganta CK, Debey BM.
> Source
> Departments of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas, USA.
> Abstract
> A 5.5-y-old spayed female ferret (Mustela putorius furo) with a history of adrenal disease, respiratory disease, and chronic obesity was evaluated for progressive lethargy and ataxia, diminished appetite, and possible polyuria and polydipsia. Physical examination revealed obesity, lethargy, tachypnea, dyspnea, a pendulous abdomen, significant weakness and ataxia of the hindlimbs, prolonged skin tenting, and mild tail-tip alopecia. Clinicopathologic analysis revealed severe hyperglycemia, azotemia, an increased anion gap, glucosuria, ketonuria, proteinuria, and hematuria. Abdominal ultrasonography showed hyperechoic hepatomegaly, bilateral adrenomegaly, splenic nodules, mild peritoneal effusion, and thickened and mildly hypoechoic limbs of the pancreas with surrounding hyperechoic mesentery. Fine-needle aspirates of the liver were highly suggestive of hepatic lipidosis. In light of a diagnosis of concurrent diabetic ketoacidosis and pancreatitis, the ferret was treated with fluid therapy, regular and long-acting insulin administration, and pain medication. However, electrolyte derangements, metabolic acidosis, dyspnea, and the clinical appearance of the ferret progressively worsened despite treatment, and euthanasia was elected. Necropsy revealed severe hepatic lipidosis, severe suppurative pancreatitis and vacuolar degeneration of pancreatic islet cells, a pancreatic β islet cell tumor, bilateral adrenal cortical adenomas, and myocardial fibrosis. To our knowledge, this case represents the first report of concurrent diabetes mellitus, pancreatitis, pancreatic β islet cell tumor (insulinoma), and adrenal disease in a domestic ferret. The simultaneous existence of 3 endocrine diseases, pancreatitis, and their associated complications is a unique and clinically challenging situation.
>
> PMID: 21838985 [PubMed - in process]


http://www.ncbi.nlm.nih.gov/pubmed/21841008

> Int J Syst Evol Microbiol. 2011 Aug 12. [Epub ahead of print]
> Classification of Pasteurella sp. B as Pasteurella oralis sp. nov.
> Christensen H, Bertelsen MF, Bojesen AM, Bisgaard M.
> Source
> University of Copenhagen;
> Abstract
> Pasteurella species B has so far only been reported from the oral cavity of dogs, cats and a ferret. In the present study, information from 15 recent isolates that included African hedgehogs (Atelerix albiventris), banded mongoose (Mungos mungo), Moholi bushbabies (Galago moholi) and pneumonia of a cat were compared to five strains investigated previously from bite wounds in humans inflicted by a cat and dog and from gingiva of a cat. rpoB gene sequence comparison showed 17 isolates including the reference strain (CCUG 19794T) to be identical in sequence, while two were closely related demonstrating 97.9 and 99.6 % similarity to strain CCUG 19794T, respectively. The closest similarity to other species was to the type strain of Pasteurella stomatis with 92.3 %. This is in the mean range of rpoB gene sequence similarity between species of the same genus within Pasteurellaceae of 90 % (range 76 - 100 %). 16S rRNA sequencing of four strains selected based on rpoB sequence comparison showed at least 99.7% similarity between strains of Pasteurella sp. B, with 96.2% similarity to the closest related species (Pasteurella canis), indicating a separate species status of Pasteurella sp. B. A separate species status was also documented when recN sequence comparisons were converted to a genome similarity of 93.7 % within Pasteurella sp. B and 59.0 % to the closest related species (P. canis). On the basis of the results of the phylogenetic analysis and phenotypic data, and since most isolates originate from the oral cavity of a diverse group of animals, these bacteria are suggested classified as Pasteurella oralis sp. nov. Previous reports of the type strain have shown ubiquinone 8, demethylmenaquinone 8 and menaquinone 8 as the major quinones. Polyamines in the type strain were reported as diaminopropane, putrescine, cadaverine, sym-norspermidine, spermidine and spermine in a previous investigation while major fatty acids of the type strain were reported to be C16:0, C16:1 ω7c and C14:0 with minor amounts of C18:0 and C18:1 ω9c. The G+C content of DNA has been reported to be 40.0 mol% of the type strain P683 T ( = CCUG 19794T = CCM 7950T) obtained from a cat.
>
> PMID: 21841008 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/21844317

> Antimicrob Agents Chemother. 2011 Aug 15. [Epub ahead of print]
> Efficacy of single intravenous injection of peramivir against influenza B virus infection in ferrets and cynomolgus macaques.
> Kitano M, Itoh Y, Kodama M, Ishigaki H, Nakayama M, Ishida H, Baba K, Noda T, Sato K, Nihashi Y,Kanazu T, Yoshida R, Torii R, Sato A, Ogasawara K.
> Source
> Department of Pathology, Shiga University of Medical Science, Otsu, Shiga 520-2192.
> Abstract
> We evaluated the efficacy of single intravenous dose peramivir for treatment of influenza B virus infection in ferrets and cynomolgus macaques in the present study. A single dose of peramivir (30 and 60 mg/kg) given to ferrets on 1 day post-infection with influenza B virus significantly reduced virus titers in nasal washes and total virus shedding as measured by areas under the curve (AUC) by 2 log(10) compared with control group. Furthermore, nasal virus titers on day 2 post infection and AUCs of the body temperature raise of the ferrets singly injected with peramivir (30 and 60 mg/kg) were lower than those of ferrets orally administered with oseltamivir phosphate (30 and 60 mg/kg/day twice daily for 3 days). In macaques infected with influenza B virus, viral titers in nasal swab fluid on days 2 and 3 post infection and body temperature after single injection with peramivir (30 mg/kg) were lower than those after oral administration with oseltamivir phosphate (30 mg/kg/day for 5 days). Two animal models used in the present study demonstrated that inhibition of viral replication at the early time point after infection was critical in reduction of AUC of virus titers and IL-6 production, resulting in amelioration of symptoms. Our results shown in animal models suggest the early treatment with a single intravenous injection of peramivir is significantly effective for the treatment of influenza B infection.
>
> PMID: 21844317 [PubMed - as supplied by publisher]

They did not use ferrets, but used data from already existing ferret studies on spinal cord injury which indicate that location affects recovery which is what may make this interesting for the FHL:

http://www.ncbi.nlm.nih.gov/pubmed/21840526

> J Biomech. 2011 Aug 12. [Epub ahead of print]
> Cervical spinal cord deformation during simulated head-first impact injuries.
> Saari A, Itshayek E, Cripton PA.
> Source
> Orthopaedic and Injury Biomechanics Group, University of British Columbia, Vancouver, Canada; Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC, Canada V6T 1Z4; International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, Canada.
> Abstract
> The relationship between bony spinal column and spinal cord injury during an injury event is not well understood. While several studies have measured spinal canal occlusion during axial impact, there has been limited work done to quantify the spinal cord compression or deformation during simulated injury. Because the cord is a viscoelastic solid it may provide resistance to bone fragments, ligaments or other elements that move into the canal and impinge it during column injury. This would differentiate the measurement of cord compression from the measurement of occlusion of an empty canal. In the present study, a novel method of visualizing and quantifying spinal cord deformation during dynamic head-first impact of ex vivo human cervical spine specimens (N=6) was developed. A radiodense, biofidelic surrogate spinal cord was imaged in the spinal canal using high speed cineradiography at 1000 frames per second. The dorsal-ventral diameter of the cord was measured at 1.5mm increments along its length for each frame of the radiographic footage. The resulting cord deformations were used to determine the theoretical neurological outcome of the impact based on published in vivo ferret studies. The corresponding probability of recovery for the spinal cord deformations in these tests ranged between 8% for atlantoaxial dislocation injury and 95% for mid-cervical spine hyperextension injury (based on the ferret data). Clinically relevant spinal column fracture patterns were produced in this study.
>
> Copyright © 2011 Elsevier Ltd. All rights reserved.
>
> PMID: 21840526 [PubMed - as supplied by publisher]




Sukie (not a vet)

Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html

"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)










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