From:
Sukie Crandall
Date: 2011-11-05 03:48:44 UTC
Subject: [ferrethealth] abstract
To: fhl <ferrethealth@yahoogroups.com>
http://www.ncbi.nlm.nih.gov/pubmed/22047620
> Amyloid. 2011 Nov 2. [Epub ahead of print]
> Ferret islet amyloid polypeptide (IAPP): characterization of in vitro and in vivo amyloidogenicity.
> Paulsson JF, Benoit-Biancamano MO, Schäffer L, Dahl K.
> Source
> Novo Nordisk A/S, Novo Nordisk Park , Måløv , Denmark.
> Abstract
> Diabetes in the domestic ferret (Mustela putorius furo) has previously been described and the purpose of this study was to evaluate if the ferret could serve as a model for the study of β-cell degeneration associated with formation of islet amyloid. The nucleotide and amino acid sequence of ferret islet amyloid polypeptide (IAPP) 1-37 was identified and the synthesized peptide was studied with regards to in vitro amyloidogenicity and potential cellular toxicity in a comparative approach to human, cat and the non-amyloidogenic rat IAPP. Ferret IAPP forms amyloid-like fibrils, but with a longer lag phase than human and cat IAPP and the aggregation process was shown to reduce cell viability of cultured β-cells, but with less potency than these two amyloidogenic counterparts. Immunohistochemistry of ferret pancreas confirmed IAPP expression in the islets of Langerhans, but no islet amyloid was found in a very limited sample size of one diabetic and five healthy ferrets. Islet amyloid has never been described in ferrets, and it is not possible to determine if it is due to lack of studies/material or to the fact that the ferret's life span is too short to present with such pathology.
>
> PMID: 22047620 [PubMed - as supplied by publisher]
Sukie (not a vet)
Recommended ferret health links:
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http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
On change for its own sake: "You can go really fast if you just jump off the cliff."
(2010, Steve Crandall)
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