Message Number: FHL14333 | New FHL Archives Search
From: Sukie Crandall
Date: 2011-11-19 16:18:13 UTC
Subject: [ferrethealth] =?windows-1252?Q?abstract_=28minks=2C_but_in_case_it_generalizes?= =?windows-1252?Q?_to_near_cousins_like_ferrets=85=29?=
To: fhl <>

> Environ Toxicol Chem. 2011 Nov 17. doi: 10.1002/etc.739. [Epub ahead of print]
> Effects of dietary exposure of mink (Mustela vison) to 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,3,7,8-tetrachlorodibenzofuran on reproduction and offspring viability and growth.
> Moore JN, Zwiernik MJ, Newsted JL, Fitzgerald SD, Link JE, Bradley PW, Kay D, Budinsky R, Giesy JP, Bursian SJ.
> Source
> Department of Animal Science, Michigan State University, East Lansing, Michigan, USA.
> Abstract
> The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-pentachlorodibenzofuran (PeCDF), and 2,3,7,8 tetrachlorodibenzofuran (TCDF) on the reproductive performance of female mink (Mustela vison) and the viability and growth of their offspring were assessed. Nine adult female mink each were randomly assigned to one of 13 dietary treatments (one control and four doses each of TCDD, PeCDF, and TCDF [2.1 to 8.4, 4.0 to 15 and 5.2 to 25 ng TCDD toxic equivalents (TEQ)/kg body wt/d]). Diets were fed from two months prior to breeding through weaning of offspring at six weeks of age. At least nine kits per treatment group were maintained on their respective diets through 27 weeks of age. There were no effects on litter size or viability of offspring. There were no consistent effects on body mass or relative organ masses of animals at any age. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and PeCDF accumulated in the liver and adipose tissue but TCDF was rapidly cleared. The lack of significant effects on reproduction and offspring viability contrasts with effects reported in mink exposed to environmentally derived PCB mixtures with equivalent TCDD potencies. This suggests that it may be inappropriate to apply toxicity reference values associated with PCB mixtures to animals also exposed to TCDD, PeCDF, or TCDF and that the World Heath Organization TCDD toxic equivalency factors for some congeners may not be appropriate for mink. Environ. Toxicol. Chem. © 2011 SETAC.
> Copyright © 2011 SETAC.
> PMID: 22095843 [PubMed - as supplied by publisher]

Sukie (not a vet)

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