From:
Sukie Crandall
Date: 2011-11-23 04:37:15 UTC
Subject: [ferrethealth] abstract
To: fhl <ferrethealth@yahoogroups.com>
With ferrets also the majority of adrenal tumors are benign yet still dangerous and handicapping if not well treated, and carcinomas still remain a problem for ferrets, too, so some studies might benefit both species with improved treatments.
http://www.ncbi.nlm.nih.gov/pubmed/22100615
> Mol Cell Endocrinol. 2011 Nov 11. [Epub ahead of print]
>
> Animal models of adrenocortical tumorigenesis.
>
> Beuschlein F, Galac S, Wilson DB.
>
> Endocrine Research Unit, Medizinische Klinik Campus Innenstadt, Klinikum der LMU,
> Ziemssenstr. 1, D-80336 Munich, Germany.
>
> Over the past decade, research on human adrenocortical neoplasia has been
> dominated by gene expression profiling of tumor specimens and by analysis of
> genetic disorders associated with a predisposition to these tumors. Although
> these studies have identified key genes and associated signaling pathways that
> are dysregulated in adrenocortical neoplasms, the molecular events accounting for
> the frequent occurrence of benign tumors and low rate of malignant transformation
> remain unknown. Moreover, the prognosis for patients with adrenocortical
> carcinoma remains poor, so new medical treatments are needed. Naturally occurring
> and genetically engineered animal models afford a means to investigate
> adrenocortical tumorigenesis and to develop novel therapeutics. This comparative
> review highlights adrenocortical tumor models useful for either mechanistic
> studies or preclinical testing. Three model species - mouse, ferret, and dog -
> are reviewed, and their relevance to adrenocortical tumors in humans is
> discussed.
>
> Copyright © 2011. Published by Elsevier Ireland Ltd.
>
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.afip.org/ferrets/index.html
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
On change for its own sake: "You can go really fast if you just jump off the cliff."
(2010, Steve Crandall)
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