From:
Sukie Crandall
Date: 2011-12-01 18:08:13 UTC
Subject: Re: [ferrethealth] Lymphoma Chemo Update and Viral Possibility
To: ferrethealth@yahoogroups.com
Yes, a form of lymphoma which is not the most common one is also sometimes called "clumping lymphoma" or "cluster lymphoma", and appears to have a sometimes silent viral trigger which happens a few YEARS before the lymphoma clump appears. Work was done long ago at the Dept of Comparative Medicine in MIT on that and they were able to trigger that form of lymphoma but were NOT able to narrow down the triggering virus. We personally have been through 2 such clumps in 30 years with ferrets.
There is an article on lymphoma which includes a mention of that, but the hosting website is gone. If you already saved copies of the articles from the AFIP site by Dr. Williams or if you have the right old issue of Ferrets magazine you will have the article in which it is mentioned.
You can go to
http://www.archive.org/index.php
and look for
http://www.afip.org/ferrets
Okay, I also find that here:
http://www.all-about-ferrets.com/support-files/lymphomaferrets.pdf
and
http://www.docstoc.com/docs/80025653/Last-Dance-C-Malignant-Lymphoma-in-Ferrets
I don't know if they had permission to use it, though I suspect at least one of them would have been very careful to get that beforehand, and know nothing about the other so do check for possible alterations though they look offhand like pdfs from the original sites, so i suspect they are likely to be reliable.
and the second page discussed that.
This is page 232 from the most recent (2nd edition) of _Biology and Diseases of the Ferret_ which lists some possible viral triggers including Aleutian Disease (AD or ADV), a retrovirus, and/or FeLV (Feline Leukemia):
<http://books.google.com/books?id=CSFN5H8RSaEC&pg=PA232&lpg=PA232&dq=williams+%2Bviral+%2Blymphoma+%2Bferrets&source=bl&ots=Mc4ZuRIO12&sig=arGp7AtbWYje0_0YI_FbuR_7nwc&hl=en&ei=Fr3XTtLRIajX0QGN2rDWDQ&sa=X&oi=book_result&ct=result&resnum=3&ved=0CDsQ6AEwAg#v=onepage&q=williams%20%2Bviral%20%2Blymphoma%20%2Bferrets&f=false>
Somewhere in the archives of the FHL it will SAY the specific scientific name attached to this type, but I am still looking at the time of including
>In fact, in 1995, researchers at the
>Massachusetts Institute of Technology
>were able to transmit lymphoma between
>ferrets with cellfree extracts, suggesting a
>possible viral cause for lymphoma, or at
>least some forms of it. The development
>of lymphoma in this experiment took several
>years in inoculated individuals, and not all
>inoculated ferrets developed lymphoma,
>but the results of this study are too intriguing
>to ignore. To date, however, a virus has yet
>to be identified or isolated from malignant
>lymphoma in ferrets.
from
http://ferrethealth.org/archive/SG11657
Ah, HERE:
immunoblastic-polymorphous lymphoma
though I do not know if that term also includes non-clumping types
from
http://ferrethealth.org/archive/FHL12967
Look also in
http://www.ferrethealth.msu.edu/
and I have not seen this before and don't have time to go through it:
http://wildpro.twycrosszoo.org/s/00dis/Miscellaneous/Lymphoma.htm#Agent
[Non-text portions of this message have been removed]
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