From:
Sukie Crandall
Date: 2011-12-08 17:07:51 UTC
Subject: Re: [ferrethealth] Re: Metronidazole Benzoate-Transdermal
To: ferrethealth@yahoogroups.com
Is there actually any study data on the use of this med transdermally yet to actually know how to get the right dosing in ferrets?
A search so far gets only this type of result showing that data are lacking:
> Your search - Helicobacter +"transdermal metronidazole" - did not match any articles.
ditto
> Your search - lumen+"transdermal metronidazole" - did not match any articles.
ditto
> Your search - stomach +"transdermal metronidazole" - did not match any articles.
ditto
> Your search - intestine +"transdermal metronidazole" - did not match any articles.
Note:
http://ferrethealth.org/archive/YG633
> I am very interested in hearing how this works out for you, and for
> any others that are trying this transdermal formula.
>
> Try as I might, I have yet to find any validation of transdermal
> Flagyl in humans. This is truly uncharted waters. My concern about
> transdermal Flagyl is that it is prescribed for the most part for
> Helicobacter and Giardia, two intraluminal GI parasites.
>
> Now for a transdermal to work properly, it must be absorbed across
> the skin, realize significant blood levels, be carried into the
> vasculature of the stomach and intestine, and secreted into the lumen
> by the epithelial cells of the stomach and intestine. While I know
> that intestinal cells have the ability to secrete some chemicals, I
> am not sure about the stomach.
>
> When administering this medication orally, it is fairly easy to
> establish the levels of antibiotic within the lumen of the intestine
> which will eliminate the parasite. It is just not clear to me
> whether blood-borne Flagyl can get to where it is needed in
> significant levels.
>
> This is NOT to say that the antibiotic isn't working - I'm just
> somewhat cautious about it at this point. I would appreciate
> continued updates on how this drug appears to be working for you, as
> well as from anyone else who is using it.
>
> With kindest regards,
>
> Bruce H. Williams, DVM
http://ferrethealth.org/archive/YG8984
> I have serious concerns about the use of transdermal Flagyl. I have
> discussed this with otehr vets on this list, as well as pharmacists.
> Metronidazole is used in ferrets for treatment of two agents - one a
> bacteria (Helicobacter) and one a protozoan (Giardia). Both of these
> agents are extracellular and live in the lumen of the stomach and
> intestine, respectively.
>
> As these agents live outside the tissues of the body, in the space
> within the gut, we rely on oral administration to get the proper
> dosage of the antibiotic to these pathogens. When you administer it
> with a cream, you get a low blood level of the antibiotic, which
> likely does not get into the lumen of the gut at all, and is probably
> of no effect.
>
> Metronidazole creams are effective in human females for vaginal
> infections, in which it is deposited into the vagina where it can be
> effective against some pathogens, but is not used in that form for GI
> problems.
>
> With kindest regards,
>
> Bruce Williams, DVM
BUT
I DID find some work indicating the rosacea is more common in those humans who have the human species of Helicobacter and other skin problems might also be more prevalent, so it might pay to know that PERHAPS ferrets with the the ferret species of Helicobacter MIGHT also get skin problems:
http://www.ncbi.nlm.nih.gov/pubmed/12224687
http://www.ncbi.nlm.nih.gov/pubmed/20650811
http://www.ncbi.nlm.nih.gov/pubmed/12010072
On Dec 8, 2011, at 10:12 AM, Florence wrote:
> Just a thought on the taste problem of metronidazole benzoate or the regular metronidazole. My vet wrote out a prescription for my Compounding Pharmacy to make a Transdermal of metronidazole benzoate, which all I had to do was wear gloves, and put a small amount into Mushu's ear (Bare part). Easy, and quick -- was done before the poor guy even knew he was scruffed and medicated. Transdermal is the way to go if you can.
>
> Yes, it was expensive, but it made both of our lives easier until he passed from something unrelated.
> Florence Love
>
>
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
[Non-text portions of this message have been removed]
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