Date: 2012-01-03 09:42:46 UTC
Subject: [ferrethealth] Re: Insulinoma, diazoxide and hind limb weakness
According to Chen (2010) dosage range for prednisone/prednisolone is 0.25 to 2 mg/kg every 12 hours. At her current weight of .76kg and concentration of 10mg/mL you can go up to 0.15mL twice a day. Prednisolone is better assimilated than prednisone.
>From the same author:
Diazoxide can also be used in combination with prednisolone
when glucocorticoids alone cannot control clinical symptoms. Recommended dosing starts at 5 to 10 mg/kg by mouth every 12 hours and can be gradually increased to a maximum of 30 mg/kg every 12 hours if lower doses do not control signs adequately (p.442).
The abstract for the paper this information is excerpted from is:
Vet Clin North Am Exot Anim Pract. 2010 Sep;13(3):439-52.
Advanced diagnostic approaches and current medical management of insulinomas and adrenocortical disease in ferrets (Mustela putorius furo).
Endocrine neoplasia is the most common tumor type in domestic ferrets, especially in middle-aged to older ferrets. Islet cell tumors and adrenocortical tumors constitute the major types of endocrine neoplasms. Insulinoma is a tumor that produces and releases excessive amounts of insulin. Evaluation of fasted blood glucose levels provides a quick diagnostic assessment for the detection of insulinomas. Use of glucocorticoids, diazoxide, and diet modification are some of the medical treatment options for insulinomas. Adrenocortical neoplasia in ferrets usually overproduces one or more sex hormones. Sex hormones which can result in progressive alopecia, vulvar swelling in females, and prostagomegaly in males. Abdominal ultrasonography and sex hormone assays can be used to diagnose adrenocortical neoplasms. Drugs such as leuprolide acetate, deslorelin acetate, and the hormone melatonin can be used to treat adrenocortical neoplasms in ferrets when surgery is not an option.
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