From: Sukie Crandall
Date: 2012-01-20 17:25:07 UTC
Subject: [ferrethealth] Virbac MUMS application, and adrenal disease general info with great links
To: fhl <firstname.lastname@example.org>, FML List <ferret-l@LISTSERV.FERRETMAILINGLIST.ORG>
Once the FDA gives an approval date for the Minor Use Minor Species application placed by Virbac U.S. and Peptech Suprelorin will be sold in the U.S.A.
As far as I know till a date for U.S. sales if given people should still contact Peptech in Australia. Just go to the FML or FHL Archives (both addies in my sig lines, and the FHL link is in multiple places on the FHL homepage, while the FML )
The importation info that hopefully quite soon will not be needed:
Suprelorin implants are deslorelin in a slow release mode. The drug is related to Lupron but lasts longer and is therefore less expensive overall. Lasting longer may also help it work better due to the effect that happens if that class of med is replaced only after it has worn off which is the same as the problem with using 24 hour Lupron except then it occurs many more times:
Suprelorin CAN be used along with Ferretonin implants and that can be a very good idea since each approaches the problem in a different way:
Natural melatonin production in the body: Melatonin production is reduced when the ferret is exposed to more light. The blue wavelength is the worst, and the green is the second worst. If a nightlight is needed in the room with the ferrets then use AMBER (and I sorely wish that all equipment lights on computers and computer related equipment were amber since so many of us have to have rooms serve multiple functions). Amber causes the least reduction in melatonin production by the pineal gland. If such products are not available near you I personally have had fine results from these people so hopefully you also will:
As an adrenal disease preventative get an annual Suprelorin implant (preferably in late Winter to early Spring but it lasts so long that the timing is less critical than it was for Lupron as long as it is done annually):
How adrenal disease is caused:
References regarding use of this product in ferrets include:
1. Vet Clin North Am Exot Anim Pract. 2010 Sep;13(3):439-52.
Advanced diagnostic approaches and current medical management of
insulinomas and adrenocortical disease in ferrets (Mustela putorius
Gulf Coast Avian & Exotics, Gulf Coast Veterinary Specialists, 1111
West Loop South, Suite 110, Houston, TX 77027, USA.
2. Am J Vet Res. 2005 May;66(5):910-4.
Clinical and endocrine responses to treatment with deslorelin acetate
implants in ferrets with adrenocortical disease.
Wagner RA, Pich=E9 CA, J=F6chle W, Oliver JW.
Division of Laboratory Animal Resources, 3500 Terrace St, S1049 BST,
University of Pittsburgh, Pittsburgh, PA 15261, USA.=09
3. Domest Anim Endocrinol. 2008 Apr;34(3):278-83. Epub 2007 Sep 10.
Luteinizing hormone-dependent Cushing's syndrome in a pet ferret
(Mustela putorius furo).
Schoemaker NJ, Kuijten AM, Galac S.
Division of Avian and Exotic Animal Medicine of the Department of
Clinical Sciences of Companion Animals, Faculty of Veterinary
Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht,The
4. Theriogenology. 2008 Jul 15;70(2):161-7. Epub 2008 Apr 25.
Use of a gonadotropin releasing hormone agonist implant as an
alternative for surgical castration in male ferrets (Mustela putorius
Schoemaker NJ, van Deijk R, Muijlaert B, Kik MJ, Kuijten AM, de Jong
FH, Trigg TE, Kruitwagen CL, Mol JA.
Department of Clinical Sciences of Companion Animals, Faculty of
Veterinary Medicine, Utrecht University, The Netherlands.N.J.
5. Vet Rec. 2010 Jan 16;166(3):74-8.
Comparison of four treatments to suppress ovarian activity in ferrets
(Mustela putorius furo).
Proh=E1czik A, Kulcs=E1r M, Trigg T, Driancourt MA, Huszenicza G.
Faculty of Veterinary Science, Szent Istv=E1n University, Istv=E1n utca 2,
1078 Budapest, Hungary.
Some treatment options when some of the potentially fatal complications of adrenal disease occur:
(and sometimes with the latter there are meds to replace some of the transport demands made on the blood, or transfusion from a healthy large male ferret can be better, and marrow transplants are even possible if not left to the last minute with that info also in the archives)
If a remaining adrenal is suppressed or atrophied, or if both adrenals come out fully or mostly:
If it is unclear if a ferret has adrenal disease the TN Panel test is very useful, but Do collect all the info and have your vet do it through direct mailing to the University of TN rather than through an intermediate lab because having an intermediate lab forward it tends to double the costs, so without that you will cover: vet appt, blood draw, sharps proper disposable costs, proper prep and packaging, and mailing as well as the U. TN cost. It always is good to not pay double for no added value, so direct sending, please!
Sukie (not a vet)
Recommended ferret health links:
all ferret topics:
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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