From:
Sukie Crandall
Date: 2012-02-06 01:28:00 UTC
Subject: Re: [ferrethealth] Re: Vanadyl Sulfate for Insulinoma
To: ferrethealth@yahoogroups.com
If your ferret is obese (and too many are) that could explain a lack of worsening:
http://diabetes.diabetesjournals.org/content/45/5/659.short
IF those results also hold for ferrets and IF later studies did not show otherwise.
Personally, I think that Tressie is right because insulinoma IS very up and down, and her comment about continued and very regular blood testing is logical and obviously safer than not doing so.
It is also possible that added attention or other changes in routine are playing a part in the current upswing, BTW.
Given what was said to be the basis for the use I think that this 1996 work is what the recommending vet is using :
http://hyper.ahajournals.org/content/28/2/219.short
> Additional Agents That Increase Insulin Sensitivity and/or Lower Plasma Lipid Concentrations
> Vanadyl sulfate and bismaltolato(oxo)vanadium (an organic vanadium compound) prevent the development of hypertension in the SHR but do not affect blood pressure in normotensive Wistar-Kyoto rats.36 37 These agents decrease plasma insulin concentrations by enhancing sensitivity to insulin, and restoration of plasma insulin to pretreatment levels reverses their antihypertensive effects.
but notice that such a mechanism could rebound in a bad way for a ferret with insulinoma.; there may be a shot term improvement followed by a worsening with this kind of mechanism because feedback loops will not decrease insulin production by beta cell tumors.
This is page 63 of a book and it notes (species?) that absorption of vanadyl is poor:
<http://books.google.com/books?hl=en&lr=&id=Z70EK_HIa8QC&oi=fnd&pg=PA63&dq=vanadyl+sulfate+insulinoma&ots=iaiU8KAAGY&sig=6L3kzGhT0VPYorm6-CCCe0C_mg8#v=onepage&q&f=false>
and that it winds up in highest concentrations in the kidneys, liver, bone, spleen
which reminds me that when you look up expert refs in Pub Med and using Google Scholar you should also look at the kidney toxicity mentioned by Dr. Murray (I am trying to recall if he also mentioned liver toxicity or if that is not a concern. Check his post.)
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
http://listserv.ferretmailinglist.org/archives/ferret-search.html
"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
[Non-text portions of this message have been removed]
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