From:
Sukie Crandall
Date: 2012-02-06 19:54:27 UTC
Subject: Re: [ferrethealth] Re: Vanadyl Sulfate for Insulinoma
To: fhl <ferrethealth@yahoogroups.com>
Yes, there is recent work indicating that the origin of beta cells ( and therefore possible of insulinomae may be from changes to the cells that create the beta cells and that could be diet independent).
> Acta Diabetol. 2011 Jul 20. [Epub ahead of print]
> Severely fibrotic pancreases from young patients with chronic pancreatitis: evidence for a ductal origin of islet neogenesis.
> Soltani SM, O'Brien TD, Loganathan G, Bellin MD, Anazawa T, Tiwari M, Papas KK,Vickers SM, Kumaravel V, Hering BJ, Sutherland DE, Balamurugan AN.
> Source
> Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN, USA.
> Abstract
> While it is known that islet cell mass increases considerably after birth, general uncertainty surrounds the source of new beta cells in humans. Chronic pancreatitis (CP) presents a natural injury model for studying postnatal beta-cell regeneration in the human pancreas. In this report, we present histological evidence from human CP pancreases to support the theory that islet neogenesis can occur from ductal precursor cells after birth. Three young patients (ages 16, 12, and 28 years) underwent total pancreatectomy for the management of CP followed by islet isolation and autologous transplantation to prevent or minimize postsurgical diabetes. In all cases, the pancreases had extensive fibrosis, a rock-like consistency, and calcifications in the ducts. During islet isolations, we observed the unusual release of islets with many ductal fragments. In histopathological evaluation of these pancreases, solid cords of cells sometimes formed islet like structures intraductally or extending from ductal structures. Immunofluorescence staining for chromogranin, insulin, proinsulin, PDX1, glucagon, and cytokeratins confirmed these structures to be composed of chromogranin-positive endocrine cells which included both β-cells and α-cells. Labeling for Ki67 to demonstrate mitotic activity showed frequent labeling of duct epithelial cells and of some periductal cells. Using insulin and wide-spectrum cytokeratin double immunofluorescent labeling, we found insulin-positive cells to be present within the ductal lumens, among the cytokeratin-positive ductal epithelium, and extending from the ductal epithelium into surrounding connective tissues, providing evidence for a ductal origin of islet neogenesis.
>
> PMID: 21773756 [PubMed - as supplied by publisher]
>
and there was work in PLoS a few years ago indicating that beta cells are produced in waves, and a diabetes researcher also points in that being a possible direction for investigation, due to increased EpCAM expression in malignant insulinomas being found in study but I don't have time to find that study though this detail should help you find it since I know you are careful to look up things well.
I am sorry that 3 of your 4 no-grain, high protein, and raw fed ferrets have gotten insulinoma, Skyla. They certainly are not alone on that score, but dealing with multiple ferrets with insulinoma is hard. The most we have ever had with insulinoma at once was two and that was hard enough.
Personally, I have to wonder how much of a role genetics is playing on the rates of insulinoma and adrenal disease. When we first had ferrets over 30 years ago both diseases were much more rare, and young cases of adrenal disease just were not encountered. In fact, we ran into lymphoma in a pancreas earlier than we ran into insulinoma itself. (There seemed to be possibly higher rates of lymphoma if the internet discussions back then are applicable, and among those participants there definitely were far more cases of ruptured spleens but that was before Helicobacter mustelae was isolated and closely studied in ferrets by James Fox's group at the MIT Dept. of Comparative Med.) It will be interesting when further genetics results come out. (Another consideration for adrenal disease might be all the green and blue equipment lights in shared rooms, too.))
Sukie (not a vet)
Recommended ferret health links:
http://pets.groups.yahoo.com/group/ferrethealth/
http://ferrethealth.org/archive/
http://www.miamiferret.org/
http://www.ferrethealth.msu.edu/
http://www.ferretcongress.org/
http://www.trifl.org/index.shtml
http://homepage.mac.com/sukie/sukiesferretlinks.html
all ferret topics:
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"All hail the procrastinators for they shall rule the world tomorrow."
(2010, Steve Crandall)
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