Message Number: FHL1843 | New FHL Archives Search
Date: Sun, 15 Jul 2007 22:46:36 EDT
Subject: [ferrethealth] Re:Adrenal prevention,etc
There has been some recent posts about how to
prevent adrenal gland disease, and there seems to
be some confusion on how some of the adrenal
medications work and how they might prevent adrenal
gland disease. I'll try to clear up some of that confusion.
Lupron and Deslorelin both work at the pituitary level to
stop the production of LH. Without LH there is no stimulation
to the adrenal glands. Without the stimulation from LH, the adrenal
gland stops producing hormones. Plus cases of hyperplasia (and
possibly even adenomas) may become smaller and may even return
to normal size with Lupron or Deslorelin treatment. However they
do not work directly on the adrenal glands. Melatonin works a little
differently. It works at the hypothalamus level to reduce LH production.
It may also work directly on the adrenal glands thru melatonin receptors
on the adrenal glands! This helps to prevent the adrenal gland from getting
As far as using these products to prevent adrenal gland disease, starting
a juvenile ferret on them may prevent that ferret from getting adrenal
Likewise starting an adult ferret on them before they have signs of adrenal
gland disease may prevent them from getting adrenal disease as they
get older. However it requires Lupron monthly, year round, for the rest of
its life and not just one dose each spring.
As far as a genetic problem and adrenal gland disease, preliminary work
done by Dr Wagner at the U of Pitt has shown a defect in a tumor suppressor
gene (P53). This defect causes a loss of tumor suppression, so tumors
can form much easier and grow much bigger. He presented this info at
the symposium in Portland.
Hope that helps clear up some of the confusion.
Jerry Murray, DVM
[Non-text portions of this message have been removed]
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